| Does Hsp70 Play a Protective Role in Tibial Dyschondroplasia? | |
Abstract/OtherAbstract
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Hsp70 was found in both normal and tibial dyschondroplasia-affected chickens suggesting that Hsp70 is expressed constitutively in the growth plate. Although the Hsp 70 content does not change significantly among the groups with lesion`s degree I to III, a decrease in the amount of total protein in the tibial growth plate of chickens with tibial dyschondroplasia was observed. There was a significant difference in the levels of Hsp70 in the growth plate of the tibia (P<0.001) between lesion of intermediary degree and lesion of severe degree. The enhancement of compressive forces in the articular cartilage might induce the chondrocytes to express induced heat-shock protein (Hsp) 70, as a defense mechanism in bone cellular survival up to score levels III. The possibility that Hsp70 is able, depending lesion`s severity, to protect and block the chondrocyte death up to score levels III, but it fails on severe lesions (degree IV), is discussed. |
Authors
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Gesiane Ribeiro, Juliana C. Bellam, Marcos Macari, Jesus A. Ferro, Joao Martins Pizauro Junior |
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Contributors
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Publication Detail
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Publisher : Asian Network for Scientific Information, Pakistan Type : - Format : - |
Date Detail
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2004 |
Subject
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Apoptosis, chondrocytes, Hsp70, tibial dyschondroplasia |
Coverage
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Relation
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Source
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International Journal of Poultry Science |
Copyright Information
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Other Details
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Languages : eng |
Export Citation
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