Document Detail
DEVELOPMENT OF AN ENZYME IMMUNOASSAY FOR P-450 OF HUMAN FETAL LIVERS (P-450 HFLa) : TRIAL OF CLINICAL APPLICATION OF P-450 HFLa AS A TUMOR MARKER
Abstract/OtherAbstract :
We established an enzyme immunoassay for human fetal liver P-450 (P-450HFLa) by utilizing the avidin-biotin-peroxidase reaction and determined that the normal range was <3.0 units/ml. In weeks 4-42 of pregnancy, the P-450HFLa level ranged from 0 to 38 units/ml. It rose during the first trimester, fell during the second trimester, and then increased again during the third trimester. After delivery, the serum P-450 HFLa concentration immediately returned to the nonpregnant level. The positivity rate was 0% in patients with benign ovarian neoplasms, 71% in those with endometriosis, and 10% in those with uterine myoma. The positivit
Authors :
岡嶋, 祐子, 稲葉, 憲之, 深沢, 一雄, 須藤, 初美, 太田, 順子, 板橋, 光司郎, 北田, 光一, 鎌滝, 哲也, 高見澤, 裕吉, オカジマ, ユウコ, Okajima, Yūko, イナバ, ノリユキ, Inaba, Noriyuki, フカサワ, イチオ, Fukasawa, Ichio, スドウ, ハツミ, Sudō, Hatsumi, オオタ, ヨリコ, Ōta, Yoriko, イタハシ, コシロウ, Itahashi, Koshirō, キタダ, ミツカズ, Kitada, Mitsukazu, カマタキ, テツヤ, Kamataki, Tetsuya, タカミザワ, ヒロヨシ, Takamizawa, Hiroyoshi, OKAJIMA, Yuko, INABA, Noriyuki, FUKASAWA, Ichio, SUDO, Hatsumi, OTA, Yoriko, ITAHASHI, Koshiro, KITADA, Mitsukazu, KAMATAKI, Tetsuya, TAKAMIZAWA, Hiroyoshi
Contributors :
千葉大学医学部産科婦人科学講座 / 川崎製鉄健康保険組合千葉病院産婦人科 / 千葉大学医学部附属病院薬剤部 / 北海道大学薬学部, Department of Obstetrics and Gynecology, School of Medicine, Chiba University / Division of Obstetrics and Gynecology, The Hospital of Kawasaki Steel Corporation Health Insurance Society / Division Hospital Pharmacy, Chiba University Hospital / Faculty of Pharmaceutical Sciences, Hokkaido University
Publication Detail :
Publisher :  千葉医学会     Type :  学術雑誌論文, 雑誌掲載論文 Journal Article, text     Format :  application/pdf    
Date Detail :
2007-11-20
Subject :
P-450HFLa, Enzyme immunoassay, Tumor marker, Gynecologic malignancy, Pregnancy, 原著, ORIGINAL PAPER, NDC:490
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Relation :
http://c-med.org/
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Languages :  eng    
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