Document Detail
CORONARY ARTHEROSCLEROSIS IN SYSTEMIC SCLEROSIS: A CROSS-SECTIONAL PILOT STUDY OF CASES AND CONTROLS
Abstract/OtherAbstract :
Objectives: 1) Determine the prevalence of subclinical coronary atherosclerosis (CA) in patients with systemic sclerosis (SSc) 2) evaluate serum proinflammatory HDL (piHDL) and transforming growth factor-Β1 (TGF-Β1) levels as potential novel markers of atherosclerotic risk in SSc. Methods: Cross-sectional study of 17 patients with SSc and 17 matched controls. Measurements included coronary calcium score; lipid profile; serum levels of high-sensitivity C-reactive protein, homocysteine, piHDL, and TGF-Β1. Results: Coronary calcium was found in 12 participants (9/17 SSc, 3/17 controls, p=0.03). The mean CCS in subjects with SSc was significantly greater compared with controls (p = 0.003). Mean values for serum homocysteine and TGF-Β1 levels were significantly greater in patients with SSc (p < 0.05). Five patients with SSc (29%), but no controls had detectable levels of piHDL (p=0.06). Conclusions: Rates of subclinical CA are greater in patients with SSc compared with controls. These findings should be confirmed in a larger study.
Authors :
KHURMA, VANDANA
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Contributors :
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Publication Detail :
Publisher :  University of Cincinnati / OhioLINK     Type :  text     Format :  -    
Date Detail :
2007
Subject :
systemic sclerosis, atherosclerosis, proinflammatory HDL, transforming growth factor-beta
Coverage :
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Relation :
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Source :
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179353380
Copyright Information :
restricted; full text unavailable until 2010-05-15, Copyright and permissions information available at the source archive
Other Details :
Languages :  English    
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