Document Detail
Concentration-dependent Effects of Peroxovanadium Compound bpV(phen) on PC12 Cell Survival
Abstract/OtherAbstract :
Peroxovanadium compounds are potent insulinomimetic agents and protein tyrosine phosphatase inhibitors. In this study, the potential toxicity of peroxovanadium complex bpV(phen) on rat pheochromocytoma PC12 cells was examined, and the mechanism by which this compound influences cell survival and/or death was explored. BpV(phen) exerted a bimodal effect on PC12 cells: survival enhancing effect at lower and death-inducing effect at higher micromolar concentrations. 1 and 3 μmol dm–3 bpV(phen) intensely induced ERK activation. In contrast, 10 and 100 μmol dm–3 bp (phen) stimulated strong and sustained JNK and p38 MAPK activation as well as caspase-3 activation that preceded bpV(phen)-induced apoptotic cell death. It is suggested that bpV(phen) might exert its action on PC12 cell survival by modulation of MAPKs and caspase-3 activation.
Authors :
Rumora, Lada, Barišić, Karmela, Petrik, József, Žanić Grubišić, Tihana
Contributors :
-
Publication Detail :
Publisher :  Croatian Chemical Society     Type :  text     Format :  pdf    
Date Detail :
2005-09-15
Subject :
peroxovanadium compounds; MAPK; caspase; apoptosis; PC12 cells
Coverage :
-
Relation :
-
Source :
Croatica Chemica Acta, CCA@chem.pmf.hr, Vol.78, No.3
Copyright Information :
Parts of the contents of Croat. Chem. Acta (e. g. figures or tables) may be reproduced without prior permission, provided reference is made to their source.
Other Details :
Languages :  en    
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