| Comparative Inhalation Toxicology of Selected Materials. | |
Abstract/OtherAbstract
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Studies are being conducted with Fischer-344 rats to determine the inhalation toxicology of a respirable power of copper-zinc alloy. Phase I involved standardization of methods, characterization of aerosols, and exposures of rats in whole-body of nose-only systems to air concentrations of 100 mg Cu-Zn/Cu m, or 100 mg titanium dioxide/Cu m. The titanium dioxide was included to determine if effects observed in exposed animals resulted from inhaling the Cu-Zn powder or inhaling a comparable amount of nuisance dust. Sham-exposed and shelf control rats were included. Rats were exposed 2.5 hr/day for 2 or 5 consecutive days, then killed for evaluations. Results include body weights, core temperatures, selected organ weights, hematology, clinical chemistry, and histopathology. Significant findings were 1) all rats were stressed when exposed in whole-body or nose-only exposure systems, 2) except for a greater body weight loss for rats exposed nose-only, indicators of stress were similar for the two types of exposure systems, 3) no consistent differences were seen between sham-exposed and TiO2-exposed rats, and 4)adverse effects from exposure to Cu-Zn alloy powder included body weight loss, decreased ability to maintain body temperature (measured in rats exposed nose-only), rhinitis, and an inflammatory response in the lung. |
Authors
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Snipes,M. B., Burt,D. G., Eidson,A. F., Hahn,F. F., Harmsen,A. G. |
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Contributors
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LOVELACE BIOMEDICAL AND ENVIRONMENTAL RESEARCH INST ALBUQUERQUE NM INHALATION TOXICOLOGY RESEARCH INST |
Publication Detail
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Publisher : - Type : Text Format : text/html |
Date Detail
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1986-09 |
Subject
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TOXICOLOGY, *COPPER ALLOYS, *TOXICOLOGY, *INHALATION, *ZINC ALLOYS, STRESSES, CONTROL, TEMPERATURE, AEROSOLS, CORES, RATS, TOXICITY, CLINICAL MEDICINE, CHEMISTRY, DUST, WEIGHT, ADVERSE CONDITIONS, LUNG, EXPOSURE(PHYSIOLOGY), RESPIRATION, TITANIUM DIOXIDE, INDICATORS, WEIGHT REDUCTION, BODY WEIGHT, HISTOPATHOLOGY, ORGANS(ANATOMY), POWDER ALLOYS, BODY TEMPERATURE, HEMATOLOGY. |
Coverage
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Relation
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Source
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DTIC AND NTIS |
Copyright Information
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APPROVED FOR PUBLIC RELEASE |
Other Details
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Languages : en |
Export Citation
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