| Changes in remnant-like particle cholesterol level during treatment of hypertension with amlodipine and cilnidipine | |
Abstract/OtherAbstract
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This study was designed to determine the effect of antihypertensive agents (calcium channel blockers) on the levels of remnant-like particle (RLP) cholesterol; a major risk factor for coronary heart disease, during treatment of hypertension. Thirty six hypertensive patients of both sexes were selected into this study. Twenty-five of them were treated with amlodipine while eleven patients were treated with cilnidipine all for 3 months. At the beginning and after 3 months of treatment, serum RLP-cholesterol levels were measured in the two treatment groups. RLP-cholesterol level was significantly reduced after clinidipine treatment while the reduction in RLP-cholesterol level after amlodipine treatment was not statistically significant. Our findings show that calcium channel blockers may lower the risk of myocardial infarction, coronary atherosclerosis and/or coronary thrombus formation through reduction in RLP-cholesterol levels during antihypertensive pharmacotherapy. Key Words: RLP-cholesterol, amlodipine, cilnidipine, hypertension treatment. <I>Journal of Biomedical Investigation</I> Vol.2(2) 2004: 72-75 |
Authors
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Ahaneku, JE; Department of Physiology, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsushi, Shizuoka-ken 431-3192;, Sakata, K; Department of Cardiology, Shizuoka General Hospital, Shizuoka, Japan.;, Urano, T; Department of Physiology, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsushi, Shizuoka-ken 431-3192;, Nagai, N; Department of Physiology, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsushi, Shizuoka-ken 431-3192;, Ihara, H; Department of Physiology, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsushi, Shizuoka-ken 431-3192;, Pawlak, R; Department of Physiology, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsushi, Shizuoka-ken 431-3192;, Takada, Y; Department of Pathophysiology, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsushi, Shizuoka-ken 431-3192;, Takada, A; Department of Physiology, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsushi, Shizuoka-ken 431-3192; |
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Contributors
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Publication Detail
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Publisher : Journal of Biomedical Investigation Association of Crop Science, Uganda Type : Peer-Reviewed Article, Format : - |
Date Detail
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2005-02-21 |
Subject
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- , RLP-cholesterol, amlodipine, cilnidipine, hypertension treatment |
Coverage
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; ; |
Relation
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- |
Source
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Journal of Biomedical Investigation - Journal of Biomedical Investigation; Vol. 2, No. 2 (2004) |
Copyright Information
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Copyright is owned by Biomedical Research Association of Nigeria. |
Other Details
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Languages : en |
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