| Biological Evaluation of Aqueous Herbal Extracts and Stirred Yoghurt Filtrate Mixture Against Alloxan-Induced Oxidative Stress and Diabetes in Rats | |
Abstract/OtherAbstract
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The aim of the present study was to investigate the biological effects of aqueous herbal extracts mixed with stirred yoghurt filtrate against alloxan-induced oxidative stress and diabetes in rats. Aqueous extracts of six medicinal plants: fenugreek, greater burdock, goat`s rue, colocynth, chicory and lupine were mixed with stirred yoghurt filtrate and used in the experiments. Blood glucose and alanine and aspartate aminotransferase (ALT and AST) activities were estimated before and after alloxan-induced oxidative stress and diabetes in rats. Obtained results showed that blood glucose levels in sera of treated rats fed on aqueous extract of medicinal plants and stirred yoghurt filtrate mixture decreased with mean values of 135.0 ± 26.85 mg/100 mL serum compared with the treated rat fed on basal diet (positive control) with mean value of 237.66 ± 14.43 mg/100 mL serum. Data showed that ALT and AST activities in sera of treated rat fed on aqueous extract of medicinal plants and stirred yoghurt filtrate mixture were nearest to the level of un-treated rats fed basal diet (negative control). The means values of ALT and AST level in treated group fed on aqueous extract of medicinal plants and stirred yoghurt filtrate mixture were 57.33 ± 20 and 189.33 ± 48.85 compared with the positive control 90 ± 31.76 and 260.00 ± 57.27 and negative control 44.66 ± 9.5 and 180.66 ± 23.58 U L<SUP>-1</SUP>, respectively. Data concluded that mixture of medicinal plant extracts and stirred yoghurt filtrate may play a role in protection against alloxan-induced oxidative stress and diabetes in rat. |
Authors
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N.A. Al-Wabel, H.M. Mousa, O.H. Omer, A.M. Abdel-Salam |
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Contributors
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Publication Detail
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Publisher : Asian Network for Scientific Information, Pakistan Type : - Format : - |
Date Detail
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2008 |
Subject
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Biological effects of aqueous herbal extracts, yoghurt, oxidative stress and diabetes |
Coverage
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Relation
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Source
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International Journal of Pharmacology |
Copyright Information
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Other Details
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Languages : eng |
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