| Antitumor activity of biflavonoids from Ouratea and Luxemburgia on human cancer cell lines | |
Abstract/OtherAbstract
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The biflavones 7,7"-dimethyllanaraflavone (1), agathisflavone (2), and 7"-methylagathisflavone (3) isolated from the leaves of Ouratea and luxenchalcone (4) isolated from the leaves and branches of Luxemburgia , as well as a mixture of 7,7"-dimethyllanaraflavone and 7"-methylagathisflavone, were assayed against HT-29 colon adenocarcinoma, NCl-H460 non-small cell lung carcinoma, MCF-7 breast cancer cell, OVCAR-3 ovarian adenocarcinoma cells, and RXF-393 renal cell carcinoma. The results show significant activities, particularly for 7,7"-dimethyllanaraflavone (IC 50 0.77 ± 0.08, 2.42 ± 0.22, and 2.59 ± 0.32 mg/ml for NCl-H460, MCF-7, and OVCAR-3, respectively), and for 7"-methylagathisflavone (IC 50 values of 4 mg/ml). Luxenchalcone revealed significant cytotoxicity on the five cell lines tested. |
Authors
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Daniel, Juliana Feijó de Souza, Alves, Cassia Cristina Fernandes, Grivicich, Ivana, da Rocha, Adriana Brondani, de Carvalho, Mário Geraldo |
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Contributors
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Publication Detail
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Publisher : Medknow Publications on behalf of Indian Pharmacological Society Type : AA Format : html |
Date Detail
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2008-02-01 |
Subject
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Antitumor agents, cancer cell lines, biflavonoids, Luxemburgia, Ouratea |
Coverage
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Origin of publication: India |
Relation
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http://www.ijp-online.com; http://www.bioline.org.br/ph |
Source
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Indian Journal of Pharmacology (ISSN: 0253-7613) Vol 39 Num 4 |
Copyright Information
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Copyright 2007 Indian Journal of Pharmacology. |
Other Details
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Languages : en |
Export Citation
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