Document Detail
Antitumor activity of biflavonoids from Ouratea   and Luxemburgia   on human cancer cell lines
Abstract/OtherAbstract :
The biflavones 7,7"-dimethyllanaraflavone (1), agathisflavone (2), and 7"-methylagathisflavone (3) isolated from the leaves of Ouratea   and luxenchalcone (4) isolated from the leaves and branches of Luxemburgia   , as well as a mixture of 7,7"-dimethyllanaraflavone and 7"-methylagathisflavone, were assayed against HT-29 colon adenocarcinoma, NCl-H460 non-small cell lung carcinoma, MCF-7 breast cancer cell, OVCAR-3 ovarian adenocarcinoma cells, and RXF-393 renal cell carcinoma. The results show significant activities, particularly for 7,7"-dimethyllanaraflavone (IC 50 0.77 ± 0.08, 2.42 ± 0.22, and 2.59 ± 0.32 mg/ml for NCl-H460, MCF-7, and OVCAR-3, respectively), and for 7"-methylagathisflavone (IC 50 values of 4 mg/ml). Luxenchalcone revealed significant cytotoxicity on the five cell lines tested.
Authors :
Daniel, Juliana Feijó de Souza, Alves, Cassia Cristina Fernandes, Grivicich, Ivana, da Rocha, Adriana Brondani, de Carvalho, Mário Geraldo
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Contributors :
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Publication Detail :
Publisher :  Medknow Publications on behalf of Indian Pharmacological Society     Type :  AA     Format :  html    
Date Detail :
2008-02-01
Subject :
Antitumor agents, cancer cell lines, biflavonoids, Luxemburgia, Ouratea
Coverage :
Origin of publication: India
Relation :
http://www.ijp-online.com; http://www.bioline.org.br/ph
Source :
Indian Journal of Pharmacology (ISSN: 0253-7613) Vol 39 Num 4
Copyright Information :
Copyright 2007 Indian Journal of Pharmacology.
Other Details :
Languages :  en    
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