Document Detail
Amiodarone Attenuates the Upregulated Matrix Metalloproteinase-2 Activity in a Rat Myocardial Infarction Model
Abstract/OtherAbstract :
Structural remodeling occurs in diverse heart diseases and affects their clinical courses. We reported that amiodarone suppresses both electrical and structural remodeling in a canine persistent atrial fi brillation model. As a mechanism for amiodarone’s effect on structural remodeling, we suggested its inhibitory effect on matrix metalloproteinase( MMP) activity. To elucidate it, we investigated the eff ect of amiodarone on MMP activity in a rat myocardial infarction model created by left coronary artery( LCA) ligation. Adult Sprague-Dawley rats were divided into sham-operated (Sham), sham-operated with amiodarone (Sham+AMD), LCA-ligated without amiodarone (MI) and LCA-ligated with amiodarone rats (MI+AMD). Amiodarone (20 mg/kg/day) was administered for 2 weeks before and for 4 weeks after operation. The hearts were excised at 4 weeks after operation. MMP-2 activity was measured by gelatin zymography. At 4 weeks after surgery, left ventricular fractional shortening was decreased in MI but not in MI+AMD rats. There was no diff erence in the infarct size between MI and MI+AMD rats (P=NS). As compared with Sham, MMP-2 activity was increased in MI (P<0.01), but not in MI+AMD (P=NS versus Sham; P<0.05 versus MI). MMP-2 activity was not increased in Sham+AMD( P=NS). Thus, amiodarone exerts an inhibitory eff ect on MMP activity. This may be related to the improvement left ventricular function in MI rats.
Authors :
Horiuchi, Daisuke, Osanai, Tomohiro, Echizen, Takashi, Ashitate, Toshihiro, Kato, Chisato, Yokoyama, Hiroaki, Hanada, Kenji, Shibutani, Shuji, Itoh, Taihei, Okumura, Ken
Contributors :
Department of Cardiology, Hirosaki University Graduate School of Medicine, Department of Cardiology, Hirosaki University Graduate School of Medicine, Department of Cardiology, Hirosaki University Graduate School of Medicine, Department of Cardiology, Hirosaki University Graduate School of Medicine, Department of Cardiology, Hirosaki University Graduate School of Medicine, Department of Cardiology, Hirosaki University Graduate School of Medicine, Department of Cardiology, Hirosaki University Graduate School of Medicine, Department of Cardiology, Hirosaki University Graduate School of Medicine, Department of Cardiology, Hirosaki University Graduate School of Medicine, Department of Cardiology, Hirosaki University Graduate School of Medicine, 弘前大学大学院医学研究科循環呼吸腎臓内科学, 弘前大学大学院医学研究科循環呼吸腎臓内科学, 弘前大学大学院医学研究科循環呼吸腎臓内科学, 弘前大学大学院医学研究科循環呼吸腎臓内科学, 弘前大学大学院医学研究科循環呼吸腎臓内科学, 弘前大学大学院医学研究科循環呼吸腎臓内科学, 弘前大学大学院医学研究科循環呼吸腎臓内科学, 弘前大学大学院医学研究科循環呼吸腎臓内科学, 弘前大学大学院医学研究科循環呼吸腎臓内科学, 弘前大学大学院医学研究科循環呼吸腎臓内科学, 堀内, 大輔, 長内, 智宏, 越前, 崇, 芦立, 俊宗, 加藤, 千里, 横山, 公章, 花田, 賢二, 澁谷, 修司, 伊藤, 太平, 奥村, 謙, ホリウチ, ダイスケ, オサナイ, トモヒロ, エチゼン, タカシ, アシタテ, トシヒロ, カトウ, チサト, ヨコヤマ, ヒロアキ, ハナダ, ケンジ, シブタニ, シュウジ, イトウ, タイヘイ, オクムラ, ケン
Publication Detail :
Publisher :  弘前大学大学院医学研究科・弘前医学会     Type :  Article, Journal Article     Format :  415367 bytes, application/pdf    
Date Detail :
2009-04-08, 2009-04-08, 2009-03-31
Subject :
structural remodeling, amiodarone, matrix metalloproteinases, myocardial infarction, 構造的モデリング, アミオダロン, マトリックスメタロプロテイナーゼ, 心筋梗塞, 内科系臨床医学, 493.23
Coverage :
-
Relation :
-
Source :
-
Copyright Information :
publisher
Other Details :
Languages :  en    
Export Citation :
APA/MLA Format     Download EndNote     Download BibTex

Previous Document:  Upregulation of Insulin-Like Growth Factor-1 Gene Expression in Cardiac Myocytes by Hypoxia : Mechan...
Next Document:  Hypoxia induces Dysfunction and Cell Death of the Rat Pancreatic Isle