Document Detail

The zebrafish zic2a-zic5 gene pair acts downstream of canonical Wnt signaling to control cell proliferation in the developing tectum.
MedLine Citation:
PMID:  17215296     Owner:  NLM     Status:  MEDLINE    
Wnt growth factors acting through the canonical intracellular signaling cascade play fundamental roles during vertebrate brain development. In particular, canonical Wnt signaling is crucial for normal development of the dorsal midbrain, the future optic tectum. Wnts act both as patterning signals and as regulators of cell growth. In the developing tectum, Wnt signaling is mitogenic; however, the mechanism of Wnt function is not known. As a step towards better understanding this mechanism, we have identified two new Wnt targets, the closely linked zic2a and zic5 genes. Using a combination of in vivo assays, we show that zic2a and zic5 transcription is activated by Tcf/Lef transcription factors in the dorsal midbrain. Zic2a and Zic5, in turn, have essential, cooperative roles in promoting cell proliferation in the tectum, but lack obvious patterning functions. Collectively these findings suggest that Wnts control midbrain proliferation, at least in part, through regulation of two novel target genes, the zic2a-zic5 gene pair.
Molly K Nyholm; Shan-Fu Wu; Richard I Dorsky; Yevgenya Grinblat
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-01-10
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  134     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-29     Completed Date:  2007-06-04     Revised Date:  2013-11-21    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  735-46     Citation Subset:  IM    
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MeSH Terms
Body Patterning
Cell Proliferation
DNA-Binding Proteins / genetics*,  physiology
Embryo, Nonmammalian
Mesencephalon / cytology,  embryology,  growth & development
Signal Transduction
Tectum Mesencephali / cytology,  embryology,  growth & development*
Transcriptional Activation
Wnt Proteins / physiology*
Zebrafish Proteins / genetics*,  physiology
Grant Support
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Wnt Proteins; 0/Zebrafish Proteins; 0/Zic5 protein, zebrafish

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