| Is your initiator really necessary? | |
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MedLine Citation:
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PMID: 3626577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is little hard evidence for the involvement of specific genotoxic initiators in the pathogenesis of the common carcinoma. Recent findings suggest that sporadic carcinogenesis is a dynamic and probabilistic process which requires a critical mass of abnormal cells for its expression, and that this requirement may distinguish the evolution of carcinomas from that of paediatric or haematologic malignancies. The proposal that specific carcinogens are neither necessary nor sufficient for tumourigenesis is consistent with the growing realization that aberrant expression of specific oncogenes is neither necessary nor sufficient for cellular transformation. These new perspectives have major implications for basic research strategy and public health policy. |
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Authors:
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R J Epstein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of theoretical biology Volume: 122 ISSN: 0022-5193 ISO Abbreviation: J. Theor. Biol. Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1987-10-15 Completed Date: 1987-10-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376342 Medline TA: J Theor Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 359-74 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinogens Cell Transformation, Neoplastic / etiology* Clone Cells Humans Models, Biological Mutation Oncogenes Probability |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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