| The yolk cell of the zebrafish blastula harbors functional apoptosis machinery. | |
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MedLine Citation:
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PMID: 22046458 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We recently described the implication of the Bcl-2 related antiapoptotic Nrz protein during early zebrafish development. Nrz knock-down induces calcium-dependent cytoskeleton remodeling leading to margin constriction and premature embryo lethality. In the YSL, nrz knock-down embryos exhibit some typical features of apoptosis such as mitochondrial transmembrane potential loss and cytochrome c release. However, downstream caspase-3 activation has not been detected so far. Here, we report that the YSL contains fully functional apoptotic machinery that can activate caspase-3 following zBax ectopic expression. Furthermore, we present evidence that caspase-3 activation is actually detectable in nrz knock-down embryos when premature margin constriction is prevented. |
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Authors:
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Nikolay Popgeorgiev; Julien Prudent; Benjamin Bonneau; Germain Gillet |
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Publication Detail:
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Type: Journal Article Date: 2011-09-01 |
Journal Detail:
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Title: Communicative & integrative biology Volume: 4 ISSN: 1942-0889 ISO Abbreviation: Commun Integr Biol Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-11-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101478473 Medline TA: Commun Integr Biol Country: United States |
Other Details:
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Languages: eng Pagination: 549-51 Citation Subset: - |
Affiliation:
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CRCL U1052 INSERM; UMS 3453 CNRS-Université Lyon 1; Centre Léon Bérard; Lyon, France. |
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