| A yeast mutant lacking mitochondrial porin is respiratory-deficient, but can recover respiration with simultaneous accumulation of an 86-kd extramitochondrial protein. | |
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MedLine Citation:
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PMID: 2438132 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A yeast mutant lacking the only known pore-forming protein of the mitochondrial outer membrane was constructed by gene disruption. The mutant retained all other major proteins of the mitochondrial outer membrane, but was severely deficient in mitochondrial cytochromes and initially did not grow on the non-fermentable carbon source, glycerol. However, it could slowly adapt to glycerol; adaptation was accompanied by the partial restoration of cytochrome levels and massive accumulation of an 86-kd polypeptide in extramitochondrial cell fractions. |
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Authors:
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M Dihanich; K Suda; G Schatz |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The EMBO journal Volume: 6 ISSN: 0261-4189 ISO Abbreviation: EMBO J. Publication Date: 1987 Mar |
Date Detail:
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Created Date: 1987-07-16 Completed Date: 1987-07-16 Revised Date: 2010-09-09 |
Medline Journal Info:
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Nlm Unique ID: 8208664 Medline TA: EMBO J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 723-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Outer Membrane Proteins
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genetics* DNA, Recombinant / metabolism Fungal Proteins / genetics*, metabolism Genes* Genes, Fungal* Ion Channels / metabolism Mitochondria / metabolism* Molecular Weight Mutation* Oxygen Consumption* Porins Saccharomyces cerevisiae / genetics*, growth & development, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Outer Membrane Proteins; 0/DNA, Recombinant; 0/Fungal Proteins; 0/Ion Channels; 0/Porins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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