Document Detail

The ydaO motif is an ATP-sensing riboswitch in Bacillus subtilis.
MedLine Citation:
PMID:  23086297     Owner:  NLM     Status:  Publisher    
We report what is to our knowledge the first natural RNA that regulates gene expression in response to intracellular ATP. Using a biochemical screen, we found that several putative riboswitches bind ATP in vitro. The ydaO motif specifically bound ATP and regulated expression of endogenous and reporter genes in response to ATP concentrations in Bacillus subtilis. This discovery demonstrates a role for RNAs in regulating gene expression in response to energy balance in bacteria.
Peter Y Watson; Martha J Fedor
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-21
Journal Detail:
Title:  Nature chemical biology     Volume:  -     ISSN:  1552-4469     ISO Abbreviation:  Nat. Chem. Biol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231976     Medline TA:  Nat Chem Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1] Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, USA. [2] Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA. [3] The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA.
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