| Resolute® and xience V® polymer-based drug-eluting stents compared in an atherosclerotic rabbit double injury model. | |
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MedLine Citation:
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PMID: 22887820 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIMS.: To evaluate differences in strut coverage, inflammation and endothelialisation between two second-generation polymer-based drug-eluting stents (DES) in an atherosclerotic rabbit double-injury iliac artery model at 28 days follow-up. METHODS AND RESULTS.: Rabbits with induced atheroma received bilateral iliac artery stents: everolimus-eluting stent (Xience V EES; Abbott Vascular), zotarolimus-eluting stent (Resolute ZES; Medtronic CardioVascular), or bare-metal stent (BMS; MultiLink Vision; Abbott Vascular). After 28 days, total neointimal coverage examined by scanning electron microscopy was >98% for all three stent types. Neointimal thickness above stent struts was decreased by 50% in Xience V EES (0.06±0.01 mm; p= 0.00001) compared with BMS (0.15±0.03 mm) and Resolute ZES (0.12±0.04 mm). Luminal area was largest for Xience V EES (3.79±0.33mm(2) ; p=0.0003 for Xience V EES vs. BMS), followed by Resolute ZES (3.46±0.45 mm(2) ; p= 0.083 for Resolute ZES vs. BMS) and BMS (3.07±0.53 mm(2) ). Percentage area stenosis was smallest for Xience V EES (17.23±3.64 %; p= 0.00001), while BMS (30.25±7.48 %) and Resolute ZES (30.79±7.15 %) did not differ. Endothelial monolayer regrowth was significantly lower in Resolute ZES (65±13%) versus BMS (79±11%; p= 0.004). There was no difference between Xience V EES (74±10%) and BMS. Xience V EES was further associated with a lower number of inflammatory cells surrounding the stent struts (7±2 per strut) in comparison to Resolute ZES (15±6; p= 0.0001) and BMS (17±9; p= 0.0005). CONCLUSION.: In this atherosclerotic rabbit model, Xience V EES suppressed neointimal thickening better, with normal endothelial regrowth as compared to BMS, and less strut-induced inflammation. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Christophe J Van Dyck; Vicky Y Hoymans; Hidde Bult; Erik Fransen; Steven Haine; Johan M Bosmans; Jean-Pierre Timmermans; Christiaan J Vrints |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-6 |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: - ISSN: 1522-726X ISO Abbreviation: Catheter Cardiovasc Interv Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Laboratory for Cellular and Molecular Cardiology, Department of Cardiology, Antwerp University Hospital, Antwerp, Belgium; Cardiology, Department of Translational Pathophysiological Research, University of Antwerp, Antwerp, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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