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Resolute® and xience V® polymer-based drug-eluting stents compared in an atherosclerotic rabbit double injury model.
MedLine Citation:
PMID:  22887820     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIMS.: To evaluate differences in strut coverage, inflammation and endothelialisation between two second-generation polymer-based drug-eluting stents (DES) in an atherosclerotic rabbit double-injury iliac artery model at 28 days follow-up. METHODS AND RESULTS.: Rabbits with induced atheroma received bilateral iliac artery stents: everolimus-eluting stent (Xience V EES; Abbott Vascular), zotarolimus-eluting stent (Resolute ZES; Medtronic CardioVascular), or bare-metal stent (BMS; MultiLink Vision; Abbott Vascular). After 28 days, total neointimal coverage examined by scanning electron microscopy was >98% for all three stent types. Neointimal thickness above stent struts was decreased by 50% in Xience V EES (0.06±0.01 mm; p= 0.00001) compared with BMS (0.15±0.03 mm) and Resolute ZES (0.12±0.04 mm). Luminal area was largest for Xience V EES (3.79±0.33mm(2) ; p=0.0003 for Xience V EES vs. BMS), followed by Resolute ZES (3.46±0.45 mm(2) ; p= 0.083 for Resolute ZES vs. BMS) and BMS (3.07±0.53 mm(2) ). Percentage area stenosis was smallest for Xience V EES (17.23±3.64 %; p= 0.00001), while BMS (30.25±7.48 %) and Resolute ZES (30.79±7.15 %) did not differ. Endothelial monolayer regrowth was significantly lower in Resolute ZES (65±13%) versus BMS (79±11%; p= 0.004). There was no difference between Xience V EES (74±10%) and BMS. Xience V EES was further associated with a lower number of inflammatory cells surrounding the stent struts (7±2 per strut) in comparison to Resolute ZES (15±6; p= 0.0001) and BMS (17±9; p= 0.0005). CONCLUSION.: In this atherosclerotic rabbit model, Xience V EES suppressed neointimal thickening better, with normal endothelial regrowth as compared to BMS, and less strut-induced inflammation. © 2012 Wiley Periodicals, Inc.
Authors:
Christophe J Van Dyck; Vicky Y Hoymans; Hidde Bult; Erik Fransen; Steven Haine; Johan M Bosmans; Jean-Pierre Timmermans; Christiaan J Vrints
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-6
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  -     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Laboratory for Cellular and Molecular Cardiology, Department of Cardiology, Antwerp University Hospital, Antwerp, Belgium; Cardiology, Department of Translational Pathophysiological Research, University of Antwerp, Antwerp, Belgium.
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