Document Detail


A work in progress: the clinical development of histone deacetylase inhibitors.
MedLine Citation:
PMID:  18487953     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been widely recognized that histone deacetylases (HDAC) are promising targets in the field of oncology. An impressive body of preclinical research points to the ability of HDAC inhibitors (HDACIs) to modulate a wide variety of cellular functions, including cell differentiation, cell cycle progression, apoptosis, cytoskeletal modifications and angiogenesis. Originally developed as epigenetic drugs because of their ability to inhibit histones deacetylation, HDACIs are now being considered also because of their effects on other acetylation-regulated proteins with pivotal roles in transformed cells. This review will highlight the clinical development of HDACIs in oncology and will try to discuss the several major open clinical issues challenging the successful clinical development of HDACIs, with a particular emphasis on the spectrum of activity of these agents, the best development strategy in solid tumors, the cardiac side effects and bio-markers to be used in clinical trials.
Authors:
Silvia Marsoni; Giovanna Damia; Gabriella Camboni
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-05-09
Journal Detail:
Title:  Epigenetics : official journal of the DNA Methylation Society     Volume:  3     ISSN:  1559-2308     ISO Abbreviation:  Epigenetics     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-07-16     Completed Date:  2008-10-02     Revised Date:  2010-01-15    
Medline Journal Info:
Nlm Unique ID:  101265293     Medline TA:  Epigenetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-71     Citation Subset:  IM    
Affiliation:
SENDO Foundation, Milano, Italy. marsonis@sendo-org.it
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / chemistry,  therapeutic use*
Benzamides
Clinical Trials as Topic
Enzyme Inhibitors / chemistry,  therapeutic use*
Histone Deacetylase Inhibitors*
Humans
Hydroxamic Acids
Neoplasms / drug therapy*,  enzymology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Benzamides; 0/Enzyme Inhibitors; 0/Histone Deacetylase Inhibitors; 0/Hydroxamic Acids

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