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A woman with premature ovarian failure induced by Tripterygium wilfordii Hook.f. gives birth to a healthy child.
MedLine Citation:
PMID:  21640345     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To inform clinicians about the reproductive damage of Tripterygium wilfordii Hook.f. (TW) associated with subsequent premature ovarian failure. DESIGN: Case report. SETTING: Reproductive medicine center in a university-affiliated hospital. PATIENT(S): A 36-year-old infertile woman presenting amenorrhea and elevated FSH levels (65.56 mIU/mL) after using TW. INTERVENTION(S): Estradiol valerate, two month course of oral contraceptives, GnRH agonist, stimulation cycle with urine FSH, triggered ovulation using 5000 IU of hCG and IVF-ET. MAIN OUTCOME MEASURE(S): Serum hormone levels, antral follicle count (AFC), oocyte retrieval number, embryo quality and birth. RESULT(S): Serum hormone levels and AFC of the POF woman were restored, and she gave birth to a healthy child after IVF-ET. Through IVF-ET she was found to have had oocyte and granulosa cell damage because of TW. CONCLUSION(S): This is a real-life manifestation of reproductive damage of TW. The medicamentous amenorrhea, hormone levels and AFC decline induced by TW are reversible, but oocyte and granulosa cell damage may be irreversible. This will help clinicians to avoid using TW for nulligravida.
Authors:
Xin Chen; Shi-Ling Chen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-1
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
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