Document Detail

IVF/ICSI with or without preimplantation genetic screening for aneuploidy in couples without genetic disorders: a systematic review and meta-analysis.
MedLine Citation:
PMID:  19629673     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the efficacy of preimplantation genetic screening to increase ongoing pregnancy rates in couples without known genetic disorders.
METHODS: Systematic review and meta-analysis of randomized controlled trials. Two reviewers independently determined study eligibility and extracted data.
RESULTS: Ten randomized trials (1,512 women) were included. The quality of evidence was moderate. Meta-analyses using a random-effects model suggest that PGS has a lower rate of ongoing pregnancies (risk ratio=0.73, 95% confidence interval 0.62-0.87) and a lower rate of live births (risk ratio=0.76, 95% confidence interval 0.64-0.91) than standard in vitro fertilization/intracytoplasmic sperm injection.
CONCLUSIONS: In women with poor prognosis or in general in vitro fertilization program, in vitro fertilization/intracytoplasmic sperm injection with preimplantation genetic screening for aneuploidy does not increase but instead was associated with lower rates of ongoing pregnancies and live births. The use of preimplantation genetic screening in daily practice does not appear to be justified.
Miguel A Checa; Pablo Alonso-Coello; Ivan Solà; Ana Robles; Ramón Carreras; Juan Balasch
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2009-07-24
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  26     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-07-31     Completed Date:  2009-11-16     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  273-83     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Hospital Universitari del Mar, Autonomous University of Barcelona, Passeig Marítim 25-29, Barcelona 08003, Spain.
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MeSH Terms
Abortion, Spontaneous
Fertilization in Vitro / methods*
Genetic Diseases, Inborn / diagnosis*,  genetics*
Maternal Age
Preimplantation Diagnosis / methods*
Randomized Controlled Trials as Topic
Sperm Injections, Intracytoplasmic / methods*
Treatment Outcome
Comment In:
J Assist Reprod Genet. 2010 Jan;27(1):65   [PMID:  20041288 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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