Document Detail


A wireless multi-channel neural amplifier for freely moving animals.
MedLine Citation:
PMID:  21240274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Conventional neural recording systems restrict behavioral experiments to a flat indoor environment compatible with the cable that tethers the subject to recording instruments. To overcome these constraints, we developed a wireless multi-channel system for recording neural signals from rats. The device takes up to 64 voltage signals from implanted electrodes, samples each at 20 kHz, time-division multiplexes them into one signal and transmits that output by radio frequency to a receiver up to 60 m away. The system introduces <4 μV of electrode-referred noise, comparable to wired recording systems, and outperforms existing rodent telemetry systems in channel count, weight and transmission range. This allows effective recording of brain signals in freely behaving animals. We report measurements of neural population activity taken outdoors and in tunnels. Neural firing in the visual cortex was relatively sparse, correlated even across large distances and was strongly influenced by locomotor activity.
Authors:
Tobi A Szuts; Vitaliy Fadeyev; Sergei Kachiguine; Alexander Sher; Matthew V Grivich; Margarida Agrochão; Pawel Hottowy; Wladyslaw Dabrowski; Evgueniy V Lubenov; Athanassios G Siapas; Naoshige Uchida; Alan M Litke; Markus Meister
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-01-16
Journal Detail:
Title:  Nature neuroscience     Volume:  14     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-28     Completed Date:  2011-03-07     Revised Date:  2011-04-06    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  263-9     Citation Subset:  IM    
Affiliation:
Program in Biophysics, Harvard University, Cambridge, Massachusetts, USA. szuts@fas.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Amplifiers, Electronic*
Animals
Electrodes, Implanted*
Equipment Design
Microelectrodes
Rats
Telemetry / instrumentation*
Comments/Corrections
Comment In:
Nat Methods. 2011 Mar;8(3):198-9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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