Document Detail

The wide spectrum of steatohepatitis: a report of four cases and a review of the literature.
MedLine Citation:
PMID:  15371930     Owner:  NLM     Status:  MEDLINE    
We report on four cases displaying the wide range of aetiological risk factors (presence or absence of family history of dyslipidaemia and cryptogenic cirrhosis, from subnormal body mass index through morbid obesity, from absent through hepatotoxic alcohol consumption), laboratory test results (from subnormal through elevated uric acid and ferritin values), ultrasonographic changes (from normal findings through 'bright liver' with or without attenuation of ultrasound beam and absence/presence of focal lesions), and histological severity of steatohepatitis (fibrosis appearing to be inversely related to the amount of liver fat but zone 3 accentuation of lesions and ballooning being observed in all cases). Cases illustrate the concepts of overlapping aetiologies of steatohepatitis (hepatitis C, diabetes and lipodystrophy); the relationships between cryptogenic cirrhosis, familial cirrhosis, non-alcoholic fatty liver disease and hepatocellular carcinoma; familial hypobetalipoproteinaemia as an aetiology of steatohepatitis; and alcoholic liver disease in the obese. These issues, which are worthy of future investigation, are reviewed.
Amedeo Lonardo; Alberto Bagni; Patrizia Tarugi; Paola Loria
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  16     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-16     Completed Date:  2005-03-08     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1043-50     Citation Subset:  IM    
Unità Operativa di Medicina Interna e Gastroenterologia, Ospedale Civile di Modena, Università di Modena e Reggio Emilia, Italy.
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MeSH Terms
Diabetes Mellitus, Type 2 / complications,  pathology
Fatty Liver* / etiology,  pathology
Genetic Predisposition to Disease
Hepatitis C / complications,  pathology
Liver / pathology
Middle Aged
Obesity / complications,  pathology
Risk Factors

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