| The wide spectrum of steatohepatitis: a report of four cases and a review of the literature. | |
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MedLine Citation:
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PMID: 15371930 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report on four cases displaying the wide range of aetiological risk factors (presence or absence of family history of dyslipidaemia and cryptogenic cirrhosis, from subnormal body mass index through morbid obesity, from absent through hepatotoxic alcohol consumption), laboratory test results (from subnormal through elevated uric acid and ferritin values), ultrasonographic changes (from normal findings through 'bright liver' with or without attenuation of ultrasound beam and absence/presence of focal lesions), and histological severity of steatohepatitis (fibrosis appearing to be inversely related to the amount of liver fat but zone 3 accentuation of lesions and ballooning being observed in all cases). Cases illustrate the concepts of overlapping aetiologies of steatohepatitis (hepatitis C, diabetes and lipodystrophy); the relationships between cryptogenic cirrhosis, familial cirrhosis, non-alcoholic fatty liver disease and hepatocellular carcinoma; familial hypobetalipoproteinaemia as an aetiology of steatohepatitis; and alcoholic liver disease in the obese. These issues, which are worthy of future investigation, are reviewed. |
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Authors:
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Amedeo Lonardo; Alberto Bagni; Patrizia Tarugi; Paola Loria |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: European journal of gastroenterology & hepatology Volume: 16 ISSN: 0954-691X ISO Abbreviation: Eur J Gastroenterol Hepatol Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-16 Completed Date: 2005-03-08 Revised Date: 2009-10-16 |
Medline Journal Info:
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Nlm Unique ID: 9000874 Medline TA: Eur J Gastroenterol Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 1043-50 Citation Subset: IM |
Affiliation:
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Unità Operativa di Medicina Interna e Gastroenterologia, Ospedale Civile di Modena, Università di Modena e Reggio Emilia, Italy. a.lonardo@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Diabetes Mellitus, Type 2 / complications, pathology Fatty Liver* / etiology, pathology Female Genetic Predisposition to Disease Hepatitis C / complications, pathology Humans Liver / pathology Male Middle Aged Obesity / complications, pathology Risk Factors |
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