| A wide spectrum of collagen vascular and autoimmune diseases in transgenic rats carrying the env-pX gene of human T lymphocyte virus type I. | |
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MedLine Citation:
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PMID: 9040015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the pathogenesis of human T lymphocyte virus type I (HTLV-I)- related diseases, the env-pX gene of HTLV-I was introduced into the germline of inbred Wistar-King-Aptekman-Hokudai rats. A wide spectrum of collagen vascular diseases was evident in the transgenic rats, including chronic destructive arthritis similar to rheumatoid arthritis, necrotizing arteritis mimicking polyarteritis nodosa, polymyositis, myocarditis, dermatitis, and chronic sialoadenitis and dacryoadenitis resembling Sjögren's syndrome in humans. Thymic atrophy with the depletion of CD4 and CD8 double-positive thymocytes was also observed. In these animals, a number of autoantibodies, including high titers of rheumatoid factor, were present in the serum. We propose that the HTLV-I env-pX gene region may play a pathogenetic role in the development of collagen vascular and autoimmune diseases associated with autoimmune phenomenon. |
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Authors:
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H Yamazaki; H Ikeda; A Ishizu; Y Nakamaru; T Sugaya; K Kikuchi; S Yamada; A Wakisaka; N Kasai; T Koike; M Hatanaka; T Yoshiki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International immunology Volume: 9 ISSN: 0953-8178 ISO Abbreviation: Int. Immunol. Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-05-22 Completed Date: 1997-05-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8916182 Medline TA: Int Immunol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 339-46 Citation Subset: IM; X |
Affiliation:
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Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Genetically Modified Arthritis, Rheumatoid / genetics, immunology Autoimmune Diseases / genetics*, immunology Dermatitis / genetics, immunology Gene Products, env / genetics, immunology Genes, env / immunology* Genes, pX / immunology* HTLV-I Antigens / genetics, immunology Humans Myocarditis / genetics, immunology Polyarteritis Nodosa / genetics, immunology Polymyositis / genetics, immunology Rats Retroviridae Proteins, Oncogenic / genetics*, immunology Sjogren's Syndrome / genetics, immunology Thymus Gland / physiopathology Transcription Factors* Viral Regulatory and Accessory Proteins |
| Chemical | |
Reg. No./Substance:
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0/Gene Products, env; 0/HTLV-I Antigens; 0/Retroviridae Proteins, Oncogenic; 0/Transcription Factors; 0/Viral Regulatory and Accessory Proteins; 0/pX protein, Human T-lymphotropic virus 1 |
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