Document Detail

A wide-field suprachoroidal retinal prosthesis is stable and well tolerated following chronic implantation.
MedLine Citation:
PMID:  23611996     Owner:  NLM     Status:  Publisher    
PURPOSE: The safety of chronic implantation of a retinal prosthesis in the suprachoroidal space has not been established. This study aimed to determine the safety of a wide-field suprachoroidal electrode array following chronic implantation using histopathological techniques and electroretinography. METHODS: A platinum electrode array in a wide silicone substrate was implanted unilaterally in the suprachoroidal space in cats (n = 7). The lead and connector were tunneled out of the orbit and positioned subcutaneously. Post-surgical recovery was assessed using fundus photography and electroretinography (ERG). Following 3 months of passive implantation, the animals were terminated and the eyes assessed for the pathological response to implantation. RESULTS: The implant was mechanically stable in the suprachoroidal space during the course of the study. The implanted eye showed a transient increase in ERG response amplitude at 2 weeks which returned to normal by 3 months. Pigmentary changes were observed at the distal end of the implant, near the optic disc. Histopathological assessment revealed a largely intact retina and a thin fibrous capsule around the suprachoroidal implant cavity. The foreign body response was minimal with sporadic presence of macrophages and no active inflammation. All implanted eyes were negative for bacterial or fungal infections. A mid-grade granuloma and thick fibrous build-up surrounded the extraocular cable. Scleral closure was maintained in 6 of 7 eyes. There were no staphylomas or choroidal incarceration. CONCLUSIONS: A wide-field retinal prosthesis was stable and well tolerated during long-term suprachoroidal implantation in a cat model. The surgical approach was reproducible and overall safe.
Joel Villalobos; David A X Nayagam; Penelope J Allen; Penelope McKelvie; Chi D Luu; Lauren N Ayton; Alexia L Freemantle; Michelle McPhedran; Meri Basa; Ceara C McGowan; Robert K Shepherd; Chris E Williams
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-23
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  -     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Bionics Institute, East Melbourne, VIC, 3002, Australia.
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