Document Detail

The who, where, and when of IgE in allergic airway disease.
MedLine Citation:
PMID:  22168998     Owner:  NLM     Status:  MEDLINE    
Allergic asthma and allergic rhinitis/conjunctivitis are characterized by a T(H)2-dominated immune response associated with increased serum IgE levels in response to inhaled allergens. Because IgE is a key player in the induction and maintenance of allergic inflammation, it represents a prime target for therapeutic intervention. However, our understanding of IgE biology remains fragmentary. This article puts together our current knowledge on IgE in allergic airway diseases with a special focus on the identity of IgE-secreting cells ("who"), their location ("where"), and the circumstances in which they are induced ("when"). We further consider the therapeutic implications of the insights gained.
Melissa Dullaers; Ruth De Bruyne; Faruk Ramadani; Hannah J Gould; Philippe Gevaert; Bart N Lambrecht
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-12-09
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  129     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-05     Completed Date:  2012-07-06     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  635-45     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
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MeSH Terms
Cell Differentiation
Cell Movement
Immunoglobulin E / immunology*
Molecular Targeted Therapy
Plasma Cells / immunology*
Respiratory Hypersensitivity / immunology*,  therapy
Grant Support
G0400106//Medical Research Council; G0501494//Medical Research Council; G1100090//Medical Research Council
Reg. No./Substance:
37341-29-0/Immunoglobulin E

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