| The who, where, and when of IgE in allergic airway disease. | |
| | |
MedLine Citation:
|
PMID: 22168998 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Allergic asthma and allergic rhinitis/conjunctivitis are characterized by a T(H)2-dominated immune response associated with increased serum IgE levels in response to inhaled allergens. Because IgE is a key player in the induction and maintenance of allergic inflammation, it represents a prime target for therapeutic intervention. However, our understanding of IgE biology remains fragmentary. This article puts together our current knowledge on IgE in allergic airway diseases with a special focus on the identity of IgE-secreting cells ("who"), their location ("where"), and the circumstances in which they are induced ("when"). We further consider the therapeutic implications of the insights gained. |
| | |
Authors:
|
Melissa Dullaers; Ruth De Bruyne; Faruk Ramadani; Hannah J Gould; Philippe Gevaert; Bart N Lambrecht |
Related Documents
:
|
12617738 - Bench-to-bedside review: functional relationships between coagulation and the innate im... 20208538 - Regulation of leukocyte recruitment by the long pentraxin ptx3. 16715068 - Is rna interference involved in intrinsic antiviral immunity in mammals? 11926618 - Innate immunity and its role against infections. 15880118 - Tlr activation triggers the rapid differentiation of monocytes into macrophages and den... 18667818 - Sanguinarine, a benzophenanthridine alkaloid, induces apoptosis in mda-mb-231 human bre... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-9 |
Journal Detail:
|
Title: The Journal of allergy and clinical immunology Volume: - ISSN: 1097-6825 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
Affiliation:
|
Laboratorium of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, Ghent, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Risk factors for new-onset cat sensitization among adults: A population-based international cohort ...
Next Document: Influence of prior growth conditions, pressure treatment parameters, and recovery conditions on the ...