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The wheat Mla homologue TmMla1 exhibits an evolutionarily conserved function against powdery mildew in both wheat and barley.
MedLine Citation:
PMID:  21208308     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The race-specific barley powdery mildew (Blumeria graminis f. sp. hordei) resistance gene Mla occurs as an allelic series and encodes CC-NB-LRR type resistance proteins. Inter-generic allele mining resulted in the isolation and characterisation of an Mla homologue from diploid wheat, designated TmMla1, which shares 78% identity with barley HvMLA1 at the protein level. TmMla1 was found to be a functional resistance gene against Blumeria graminis f. sp. tritici in wheat, hereby providing an example of R gene orthologs controlling the same disease in two different species. TmMLA1 exhibits race-specific resistance activity and its N-terminal coiled-coil domain interacts with the barley transcription factor HvWRKY1. Interestingly, TmMLA1 was not functional in barley transient assays. Replacement of the TmMLA1 LRR domain with that of HvMLA1 revealed that this fusion protein conferred resistance against B. graminis f. sp. hordei isolate K1 in barley. Thus, TmMLA1 not only confers resistance in wheat but possibly also in barley against an as yet unknown barley powdery mildew race. The conservation of functional R gene orthologs over at least 12 million years is surprising given the observed rapid breakdown of Mla-based resistance against barley mildew in agricultural ecosystems. This suggests a high stability of Mla resistance in the natural environment before domestication.
Authors:
Tina Jordan; Sabine Seeholzer; Simon Schwizer; Armin Töller; Imre E Somssich; Beat Keller
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Publication Detail:
Type:  Journal Article     Date:  2011-01-05
Journal Detail:
Title:  The Plant journal : for cell and molecular biology     Volume:  65     ISSN:  1365-313X     ISO Abbreviation:  Plant J.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9207397     Medline TA:  Plant J     Country:  England    
Other Details:
Languages:  eng     Pagination:  610-21     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. The Plant Journal © 2011 Blackwell Publishing Ltd.
Affiliation:
Institute of Plant Biology, University of Zürich, Zollikerstrasse 107, CH-8008 Zürich, Switzerland Max-Planck-Institute for Plant Breeding, Department of Plant-Microbe Interactions, Carl-von-Linné Weg 10, D-50829 Koeln, Germany.
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