| The way out - what we know and don't know about herpesvirus nuclear egress. | |
| | |
MedLine Citation:
|
PMID: 23057731 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Herpesvirus capsids are assembled in the nucleus of infected cells whereas final maturation occurs in the cytosol. To access the final maturation compartment, intranuclear capsids have to cross the nuclear envelope which represents a formidable barrier. They do so by budding at the inner nuclear membrane, thereby forming a primary enveloped particle residing in the perinuclear cleft. Formation of primary envelopes is driven by a heterodimeric complex of two conserved herpesviral proteins, designated in the herpes simplex virus nomenclature as pUL34, a tail-anchored transmembrane protein located in the nuclear envelope, and pUL31. This nuclear egress complex (NEC) recruits viral and cellular kinases to soften the nuclear lamina and allowing access of capsids to the NEC. How capsids are recruited to the budding site and into the primary virus particle is still not completely understood, nor is the composition of the primary enveloped virion in the perinuclear cleft. Fusion of the primary envelope with the outer nuclear membrane then results in translocation of the capsid to the cytosol. This fusion event is clearly different from fusion during infectious entry of free virions into target cells in that it does not require the conserved essential core herpesvirus fusion machinery. Nuclear egress can thus be viewed as a vesicle (primary envelope)-mediated transport of cargo (capsids) through the nuclear envelope, a process which had been unique in cell biology. Only recently has a similar process been identified in Drosophila for nuclear egress of large ribonucleoprotein complexes. Thus, herpesviruses appear to subvert a hitherto cryptic cellular pathway for translocation of capsids from the nucleus to the cytosol. |
| | |
Authors:
|
Thomas C Mettenleiter; Frederik Müller; Harald Granzow; Barbara G Klupp |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-12 |
Journal Detail:
|
Title: Cellular microbiology Volume: - ISSN: 1462-5822 ISO Abbreviation: Cell. Microbiol. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883691 Medline TA: Cell Microbiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 Blackwell Publishing Ltd. |
Affiliation:
|
Institutes of Molecular Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mitochondrial control region I and microsatellite analyses of endangered Philippine hornbill species...
Next Document: The impact of peer victimization on later maladjustment: mediating and moderating effects of hostile...