Document Detail

A water-soluble extract from Grifola frondosa, maitake mushroom, decreases lipid droplets in brown adipocyte tissue cells.
MedLine Citation:
PMID:  19155589     Owner:  NLM     Status:  MEDLINE    
We investigated the effect of a water-soluble extract from Grifola frondosa, the maitake mushroom, on lipid droplets in brown adipocyte tissue (BAT) cells. This water-soluble extract inhibits the conversion of pre white adipocyte tissue (WAT) cells but does not inhibit that of pre BAT cells. It reduces the amount of accumulated triglycerides (TG) in BAT cells. The glycerol-3-phosphate dehydrogenase (GPDH) activities of BAT cells decreased, but the expression of uncoupling protein 1 (UCP1) levels increased. These results suggest that maitake extract inhibits TG accumulation-related energy metabolism.
Katsuhiko Minamino; Yumi Nagasawa; Masaru Ohtsuru
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  54     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  497-500     Citation Subset:  IM    
Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women's University, Nishinomiya, Japan.
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MeSH Terms
Adipocytes, Brown / drug effects*,  metabolism
Adipocytes, White / drug effects*,  metabolism
Cell Differentiation / drug effects
Glucose / antagonists & inhibitors
Glucose Transporter Type 4 / metabolism
Glycerolphosphate Dehydrogenase / metabolism*
Ion Channels / metabolism*
Mitochondrial Proteins / metabolism*
Plant Extracts / pharmacology*
Triglycerides / metabolism*
Reg. No./Substance:
0/Glucose Transporter Type 4; 0/Ion Channels; 0/Mitochondrial Proteins; 0/Plant Extracts; 0/Triglycerides; 0/mitochondrial uncoupling protein; 50-99-7/Glucose; EC 1.1.-/Glycerolphosphate Dehydrogenase

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