| The warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen? | |
| | |
MedLine Citation:
|
PMID: 18393789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cells can obtain energy through the oxygen-dependent pathway of oxidative phosphorylation (OXPHOS) and through the oxygen-independent pathway of glycolysis. Since OXPHOS is more efficient in generating ATP than glycolysis, it is recognized that the presence of oxygen results in the activation of OXPHOS and the inhibition of glycolysis (Pasteur effect). However, it has been known for many years that cancer cells and non-malignant proliferating cells can activate glycolysis in the presence of adequate oxygen levels (aerobic glycolysis or Warburg effect). Accumulating evidence suggests that the persistent activation of aerobic glycolysis in tumor cells plays a crucial role in cancer development; the inhibition of the increased glycolytic capacity of malignant cells may therefore represent a key anticancer strategy. Although some important knowledge has been gained in the last few years on this growing field of research, the basis of the Warburg effect still remains poorly understood. This communication analyzes why cancer cells switch from OXPHOS to glycolysis in the presence of adequate oxygen levels, and how these cells manage to avoid the inhibition of glycolysis induced by oxygen. Several strategies and drugs that may interfere with the glycolytic metabolism of cancer cells are also shown. This information may help develop anticancer approaches that may have clinical relevance. |
| | |
Authors:
|
Miguel López-Lázaro |
Related Documents
:
|
7647919 - Detection of hydroxyl radical in intact cells of chlorella vulgaris. 18253049 - The effects of lipopolysaccharide-induced reactive oxygen species were blunted by calci... 7378899 - Quantitative correlation between the reduction of nitroblue tetrazolium and the oxygen ... 20072909 - Identification of ros using oxidized dcfda and flow-cytometry. 1257749 - Marine oscillatoria (trichodesmium): explanation for aerobic nitrogen fixation without ... 15804439 - Immunohistochemical study of p47phox and gp91phox distributions in rat brain. 155659 - Inhibition of mixed-lymphocyte reaction by quinine and lack of effect on plaque-forming... 3961819 - Glutathione- and cysteine-mediated cytotoxicity of allyl and benzyl isothiocyanate. 1473269 - Normal and ha-ras-1 oncogene transformed buffalo rat liver (brl) cells show differentia... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Anti-cancer agents in medicinal chemistry Volume: 8 ISSN: 1871-5206 ISO Abbreviation: - Publication Date: 2008 Apr |
Date Detail:
|
Created Date: 2008-04-08 Completed Date: 2008-05-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101265649 Medline TA: Anticancer Agents Med Chem Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 305-12 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, University of Seville, Spain. mlopezlazaro@us.es |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antineoplastic Agents / pharmacology, therapeutic use Glycolysis / drug effects, physiology* Humans Neoplasms / drug therapy, metabolism* Oxygen / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diazo-containing molecular constructs as potential anticancer agents: from diazo[b]fluorene natural ...
Next Document: Cancer chemoprevention by garlic and its organosulfur compounds-panacea or promise?