| The wall teichoic acid and lipoteichoic acid polymers of Staphylococcus aureus. | |
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MedLine Citation:
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PMID: 19896895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Staphylococci and most other Gram-positive bacteria incorporate complex teichoic acid (TA) polymers into their cell envelopes. Several crucial roles in Staphylococcus aureus fitness and cell wall maintenance have been assigned to these polymers, which are either covalently linked to peptidoglycan (wall teichoic acid, WTA) or to the cytoplasmic membrane (lipoteichoic acid, LTA). However, the exact TA structures, functions, and biosynthetic pathways are only superficially understood. Recently, most of the enzymes mediating TA biosynthesis have been identified and mutants lacking or with defined changes in WTA or LTA have become available. Their characterization has revealed crucial roles of TAs in protection against harmful molecules and environmental stresses; in control of enzymes directing cell division or morphogenesis and of cation homeostasis; and in interaction with host or bacteriophage receptors and biomaterials. Accordingly, several in vivo studies have demonstrated the importance of WTA and LTA in S. aureus colonization, infection, and immune evasion. TAs and enzymes required for TA biosynthesis represent attractive candidates for novel vaccines and antibiotics and are targeted by recently developed antibacterial therapeutics. |
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Authors:
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Guoqing Xia; Thomas Kohler; Andreas Peschel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-11-06 |
Journal Detail:
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Title: International journal of medical microbiology : IJMM Volume: 300 ISSN: 1618-0607 ISO Abbreviation: Int. J. Med. Microbiol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2010-05-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100898849 Medline TA: Int J Med Microbiol Country: Germany |
Other Details:
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Languages: eng Pagination: 148-54 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier GmbH. All rights reserved. |
Affiliation:
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Division of Cellular and Molecular Microbiology, Institute of Medical Microbiology and Hygiene, University of T?bingen, Elfriede-Aulhorn-Strasse 6, D-72076 T?bingen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Membrane / chemistry, metabolism Cell Wall / chemistry, metabolism Host-Pathogen Interactions Humans Staphylococcal Infections / metabolism, microbiology*, prevention & control Staphylococcal Vaccines / pharmacology Staphylococcus aureus / chemistry, physiology* Teichoic Acids* / chemistry, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Staphylococcal Vaccines; 0/Teichoic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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