| A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLD. | |
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MedLine Citation:
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PMID: 16009889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the patterns of MRI brain atrophy in patients with ALS with and without clinically evident frontotemporal lobar dementia (FTLD) using voxel-based morphometry (VBM). METHODS: Voxel-based morphometry was used to compare T1-weighted MRI images obtained from ten ALS patients with FTLD, ten ALS patients who were cognitively and behaviorally normal, and 22 control subjects. Images from patients and controls were spatially pre-processed using a study-specific, customized template and a priori images. A statistical threshold of p < 0.05 corrected for multiple comparisons determined significance. RESULTS: A common pattern of gray matter atrophy was seen in both ALS and ALS/FTLD patients when compared to controls that involved the bilateral motor/premotor cortices, the left middle and inferior frontal gyri, the anterior portion of the superior frontal gyri, the superior temporal gyri, the temporal poles and left posterior thalamus. Most of the frontal regions were significantly more atrophied in the ALS/FTLD group than in the ALS group. No significant differences were found in white matter volumes. CONCLUSIONS: Patients with ALS and ALS associated with frontotemporal lobar degeneration exhibit widespread gray matter atrophy in frontotemporal regions. This finding supports the idea of a clinical and anatomic continuum between ALS and frontotemporal lobar degeneration. |
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Authors:
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J L Chang; C Lomen-Hoerth; J Murphy; R G Henry; J H Kramer; B L Miller; M L Gorno-Tempini |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurology Volume: 65 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-12 Completed Date: 2006-02-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 75-80 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, University of California San Francisco, CA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Aged Amyotrophic Lateral Sclerosis / diagnosis*, pathology, physiopathology Atrophy / diagnosis*, pathology, physiopathology Brain / pathology*, physiopathology Brain Mapping / methods Bulbar Palsy, Progressive / diagnosis, pathology, physiopathology Cerebral Cortex / pathology, physiopathology Comorbidity Dementia / diagnosis*, pathology, physiopathology Disease Progression Female Humans Magnetic Resonance Imaging / methods* Male Middle Aged Neuropsychological Tests Thalamus / pathology, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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1 P50 AG-03-006-01/AG/NIA NIH HHS; 5P01 AG019724-02/AG/NIA NIH HHS; M01 RR00079/RR/NCRR NIH HHS; R01 NS50915/NS/NINDS NIH HHS |
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