Document Detail


A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLD.
MedLine Citation:
PMID:  16009889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the patterns of MRI brain atrophy in patients with ALS with and without clinically evident frontotemporal lobar dementia (FTLD) using voxel-based morphometry (VBM). METHODS: Voxel-based morphometry was used to compare T1-weighted MRI images obtained from ten ALS patients with FTLD, ten ALS patients who were cognitively and behaviorally normal, and 22 control subjects. Images from patients and controls were spatially pre-processed using a study-specific, customized template and a priori images. A statistical threshold of p < 0.05 corrected for multiple comparisons determined significance. RESULTS: A common pattern of gray matter atrophy was seen in both ALS and ALS/FTLD patients when compared to controls that involved the bilateral motor/premotor cortices, the left middle and inferior frontal gyri, the anterior portion of the superior frontal gyri, the superior temporal gyri, the temporal poles and left posterior thalamus. Most of the frontal regions were significantly more atrophied in the ALS/FTLD group than in the ALS group. No significant differences were found in white matter volumes. CONCLUSIONS: Patients with ALS and ALS associated with frontotemporal lobar degeneration exhibit widespread gray matter atrophy in frontotemporal regions. This finding supports the idea of a clinical and anatomic continuum between ALS and frontotemporal lobar degeneration.
Authors:
J L Chang; C Lomen-Hoerth; J Murphy; R G Henry; J H Kramer; B L Miller; M L Gorno-Tempini
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  65     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-12     Completed Date:  2006-02-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  75-80     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, University of California San Francisco, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Aged
Amyotrophic Lateral Sclerosis / diagnosis*,  pathology,  physiopathology
Atrophy / diagnosis*,  pathology,  physiopathology
Brain / pathology*,  physiopathology
Brain Mapping / methods
Bulbar Palsy, Progressive / diagnosis,  pathology,  physiopathology
Cerebral Cortex / pathology,  physiopathology
Comorbidity
Dementia / diagnosis*,  pathology,  physiopathology
Disease Progression
Female
Humans
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Neuropsychological Tests
Thalamus / pathology,  physiopathology
Grant Support
ID/Acronym/Agency:
1 P50 AG-03-006-01/AG/NIA NIH HHS; 5P01 AG019724-02/AG/NIA NIH HHS; M01 RR00079/RR/NCRR NIH HHS; R01 NS50915/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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