Document Detail

von Willebrand's disease prevents occlusive thrombosis in stenosed and injured porcine coronary arteries.
MedLine Citation:
PMID:  3488139     Owner:  NLM     Status:  MEDLINE    
We studied the role of von Willebrand factor in coronary thrombosis in normal, heterozygous, and homozygous von Willebrand's disease pigs by producing coronary stenosis with a Goldblatt clamp positioned around the left anterior descending coronary artery. Flow velocity was assessed by a 20-MHz Doppler velocity probe distal to the Goldblatt clamp. Myocardial extracellular potassium levels were measured by potassium-sensitive electrodes in myocardium supplied by the left anterior descending artery. Whereas stenosis sufficient to block reactive hyperemia to a 20-second occlusion produced an elevation of myocardial extracellular potassium, it produced neither spontaneous cyclic flow reductions nor permanent cessation of coronary blood flow velocity. Injury of the coronary artery at the stenosis site with spring-loaded forceps produced cyclic flow reductions or permanent cessation of flow in eight of nine phenotypically normal pigs. On the other hand, flow variations occurred in none of the 10 von Willebrand's disease pigs, including four given purified von Willebrand factor at a dose that failed to correct the bleeding time (p less than 0.001, chi 2 test). Permanent cessation of flow was caused by an occlusive platelet-fibrin-red-blood-cell thrombus. Scanning electron micrographs from pigs with cyclic flow variations and from von Willebrand's disease pigs showed injured endothelium covered by adherent platelets, red and white blood cells, and fibrin. These data suggest an important role of native von Willebrand factor in sudden occlusive arterial thrombosis following stenosis and intimal injury.
T C Nichols; D A Bellinger; T A Johnson; M A Lamb; T R Griggs
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  59     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  15-26     Citation Subset:  IM    
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MeSH Terms
Blood Flow Velocity
Constriction, Pathologic / pathology
Coronary Circulation
Coronary Disease / pathology*,  prevention & control
Coronary Vessels / pathology*
Fibrin / metabolism
Microscopy, Electron, Scanning
Myocardium / metabolism
Platelet Aggregation
Potassium / metabolism
von Willebrand Diseases / genetics,  pathology*
von Willebrand Factor / physiology*
Grant Support
Reg. No./Substance:
0/von Willebrand Factor; 7440-09-7/Potassium; 9001-31-4/Fibrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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