| von Willebrand factor: at the crossroads of bleeding and thrombosis. | |
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MedLine Citation:
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PMID: 22477538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemostasis and thrombosis represent two sides of the same coin. Hemostasis maintains blood fluidity in the vascular system while allowing for rapid thrombus formation to prevent excessive hemorrhage after blood vessel injury. Thrombosis is a pathologic extension of the normal hemostatic mechanism, occurring when unwanted clot formation develops in certain pathological situations. The molecular mechanisms underlying both phenomena are fundamentally identical. One of the key players in both processes is the plasma glycoprotein von Willebrand factor, which perfectly illustrates this duality between hemostatic and thrombotic mechanisms. The purpose of this review is to discuss novel findings on the role of von Willebrand factor at this interface, and how some of these findings may help develop new therapeutic strategies. |
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Authors:
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Cécile V Denis; Peter J Lenting |
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Publication Detail:
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Type: Journal Article; Review Date: 2012-04-05 |
Journal Detail:
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Title: International journal of hematology Volume: 95 ISSN: 1865-3774 ISO Abbreviation: Int. J. Hematol. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-24 Completed Date: 2012-08-14 Revised Date: 2013-06-12 |
Medline Journal Info:
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Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: Japan |
Other Details:
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Languages: eng Pagination: 353-61 Citation Subset: IM |
Affiliation:
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INSERM U770, 80 rue du General Leclerc, 94276 Le Kremlin-Bicêtre, France. cecile.denis@inserm.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Hemorrhage / blood, genetics, metabolism* Humans Mutation Protein Conformation Protein Multimerization Thrombosis / blood, genetics, metabolism* von Willebrand Factor / chemistry, genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/von Willebrand Factor |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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