Document Detail

von Willebrand factor antigen in hypertrophic osteoarthropathy.
MedLine Citation:
PMID:  1613707     Owner:  NLM     Status:  MEDLINE    
Recent evidence suggests that a key feature in the pathogenesis of hypertrophic osteoarthropathy (HOA) is an enhanced local platelet vessel wall interaction in the affected extremities. In our investigation we measured plasma levels of von Willebrand Factor Antigen (vWF:Ag; ELISA assay), a marker of platelet and/or endothelial activation, in 5 patients with the primary form of HOA and in 6 patients with the secondary form (due to cyanotic heart disease). Seven subjects matched for sex and age were used as controls. Patients showed statistically significantly higher levels of vWF:Ag in the primary (163.8 +/- 13.9%) and secondary form (152.6 +/- 9.6%, p less than 0.001 for both) when compared to controls (100.4 +/- 6.3%). Our results support the notion that platelet endothelial cell interaction may play a key role in the development of HOA.
M Matucci-Cerinic; M Martinez-Lavin; F Rojo; C Fonseca; B M Kahaleh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  19     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-07-24     Completed Date:  1992-07-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  765-7     Citation Subset:  IM    
Institute of Internal Medicine, University of Florence, Italy.
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MeSH Terms
Antigens / analysis*
Endothelium, Vascular / pathology
Enzyme-Linked Immunosorbent Assay
Osteoarthropathy, Primary Hypertrophic / blood,  etiology,  immunology*
Statistics as Topic
von Willebrand Factor / immunology
Reg. No./Substance:
0/Antigens; 0/Von Willebrand antigen; 0/von Willebrand Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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