Document Detail


von Willebrand Factor Inhibition Improves Endothelial Function in Patients with Stable Angina.
MedLine Citation:
PMID:  23233321     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ALX-0081 is a novel nano-antibody inhibiting von Willebrand factor (vWF). We evaluated whether direct inhibition of vWF by ALX-0081 improves endothelial function. Stable patients (pts, n = 55) with single vessel disease undergoing percutaneous coronary intervention (PCI) were randomized to ALX-0081 (n = 38) or placebo (n = 17). vWF inhibition was assessed by vWF antigen level (vWF:Ag) and activity by ristocetin test (vWF:RiCo). Endothelial function was assessed before (BL), 6 h and 24 h after PCI by: (a) endothelial peripheral arterial tonometry (Endoscore); (b) endothelial microparticles (EMPs) by flow cytometry. vWF:Ag and vWF:RiCo decreased within 1 h from ALX-0081. In the placebo group, no significant Endoscore changes occurred from BL to 24 h. In ALX-0081 group, Endoscore increased from BL to 24 h (p = 0.014). A decrease in EMPs was observed after ALX-0081 (p < 0.01), while no changes occurred in placebo pts. An inhibition of vWF with ALX-0081 significantly improves peripheral endothelial function.
Authors:
Olivier Muller; Jozef Bartunek; Michalis Hamilos; Catalina Trana Berza; Fabio Mangiacapra; Argyrios Ntalianis; Kristof Vercruysse; Christian Duby; William Wijns; Bernard De Bruyne; Guy R Heyndrickx; Marc Vanderheyden; Josefin-Beate Holz; Emanuele Barbato
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-12
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  -     ISSN:  1937-5395     ISO Abbreviation:  J Cardiovasc Transl Res     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Cardiovascular Center Aalst OLV Clinic, Moorselbaan 164, B-9300 Aalst, Belgium.
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