Document Detail

The vicious circle of ischemic left ventricular dysfunction.
MedLine Citation:
PMID:  7726118     Owner:  NLM     Status:  MEDLINE    
Myocardial ischemia tends to be self-propagating, and minor events such as plaque rupture can lead to the catastrophic sequelae of myocardial infarction and death. The biology of the endothelium and the cardiac myocyte is crucial to the development of these vicious circles. The abnormal responses of the endothelial cell in atherosclerosis tend to provoke and propagate ischemia, and because of the limited metabolic reserve of the myocyte, even short periods of ischemia can lead to left ventricular dysfunction and arrhythmias. This article examines the clinical implications of the disordered biology of the endothelial cell and the myocyte that is the basis for ischemic left ventricular dysfunction.
C Knight; K Fox
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  75     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-05-23     Completed Date:  1995-05-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  10E-15E     Citation Subset:  AIM; IM    
Royal Brompton National Heart and Lung Hospital, London, United Kingdom.
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MeSH Terms
Coronary Vessels / physiopathology
Endothelium, Vascular / physiopathology*
Myocardial Ischemia / etiology,  physiopathology*
Ventricular Dysfunction, Left / etiology,  physiopathology*

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