| The vicious circle of ischemic left ventricular dysfunction. | |
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MedLine Citation:
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PMID: 7726118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myocardial ischemia tends to be self-propagating, and minor events such as plaque rupture can lead to the catastrophic sequelae of myocardial infarction and death. The biology of the endothelium and the cardiac myocyte is crucial to the development of these vicious circles. The abnormal responses of the endothelial cell in atherosclerosis tend to provoke and propagate ischemia, and because of the limited metabolic reserve of the myocyte, even short periods of ischemia can lead to left ventricular dysfunction and arrhythmias. This article examines the clinical implications of the disordered biology of the endothelial cell and the myocyte that is the basis for ischemic left ventricular dysfunction. |
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Authors:
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C Knight; K Fox |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The American journal of cardiology Volume: 75 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-05-23 Completed Date: 1995-05-23 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 10E-15E Citation Subset: AIM; IM |
Affiliation:
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Royal Brompton National Heart and Lung Hospital, London, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Vessels
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physiopathology Endothelium, Vascular / physiopathology* Humans Myocardial Ischemia / etiology, physiopathology* Ventricular Dysfunction, Left / etiology, physiopathology* |
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