Document Detail

The vestibular hair cells: post-transductional signal processing.
MedLine Citation:
PMID:  9481798     Owner:  NLM     Status:  MEDLINE    
Hair cells in mechanosensory systems transduce mechanical stimuli into biological signals to be presented to and analyzed by the brain. Vestibular hair cells transduce stimuli primarily associated with the organism's orientation and motion in space. When examined superficially it may appear that the hair cells act as passive transducers whereby mechanical stimulation of their hair bundle results in transmitter release at their afferent synapses. In fact, hair cell functions are more complicated, and the mechanical signals are heavily processed even before being encoded in afferent nerve activity. Hair cells are different from one another in morphology, biophysics, transmitter and transmitter receptor complements, not only across different organs (as one might expect), but even in the same organ. This review focuses on hair cell morpho-physiological properties, ionic conductances, neurotransmitters/modulators and their receptors, second messengers and effectors. Special features of hair cell neurotransmission, as the synaptic body and the presence of autoreceptors and local circuits, are also discussed, as is the possibility of a differential modulation of hair cell transmitter release in the resting and mechanically-stimulated states.
P S Guth; P Perin; C H Norris; P Valli
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Progress in neurobiology     Volume:  54     ISSN:  0301-0082     ISO Abbreviation:  Prog. Neurobiol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-24     Completed Date:  1998-03-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370121     Medline TA:  Prog Neurobiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  193-247     Citation Subset:  IM; S    
Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
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MeSH Terms
Hair Cells, Vestibular / physiology*
Signal Transduction / physiology*
Grant Support

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