| A very strict guideline reduces the number of erythrocyte transfusions in preterm infants. | |
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MedLine Citation:
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PMID: 18544122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Benefits of adopting restrictive guidelines for erythrocyte transfusions are still controversial. The objective of this study was to verify if a very strict guideline could reduce erythrocyte transfusions in preterm infants without adverse outcomes. MATERIALS AND METHODS: Two prospective cohorts of neonates with gestational age < 37 weeks and birth weight < 1500 g were studied. Neonates born in Period 1 were submitted to a strict guideline for erythrocyte transfusions. In Period 2, a new stricter protocol was introduced. Infants of both periods were compared regarding number of transfusions and clinical outcome. RESULTS: The median number of transfusions decreased from 2 (1 to 14) in Period 1 to 1 (1-9), P = 0.001, in Period 2. The linear regression multivariate analysis showed that the implementation of the stricter guideline was associated with a reduction in the number of transfusions received by patients by 0.55 (95% confidence interval: -0.08; -1.02) units/patients. Number of apnea episodes, weight at 28 days of life and days of hospital stay were similar in both periods. Intra-hospital death was lower in Period 2. CONCLUSION: A very strict guideline reduced the number of erythrocyte transfusions in preterm infants, without threatening their clinical course. |
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Authors:
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A F M A Mimica; A M N dos Santos; D H F da Cunha; R Guinsburg; J O Bordin; A Chiba; M M O Barros; B I Kopelman |
Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article Date: 2008-06-09 |
Journal Detail:
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Title: Vox sanguinis Volume: 95 ISSN: 1423-0410 ISO Abbreviation: Vox Sang. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-13 Completed Date: 2008-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413606 Medline TA: Vox Sang Country: England |
Other Details:
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Languages: eng Pagination: 106-11 Citation Subset: IM |
Affiliation:
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Division of Neonatal Medicine, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
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epidemiology,
prevention & control Apnea / epidemiology Cerebral Hemorrhage / epidemiology Cohort Studies Erythrocyte Transfusion / standards, utilization* Female Gestational Age Guideline Adherence* Hematocrit Hospital Mortality Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases / epidemiology, prevention & control, therapy* Infant, Small for Gestational Age Infant, Very Low Birth Weight Length of Stay / statistics & numerical data Male Phlebotomy / adverse effects Positive-Pressure Respiration / utilization Practice Guidelines as Topic* Prospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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