Document Detail

The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations.
MedLine Citation:
PMID:  20106645     Owner:  NLM     Status:  MEDLINE    
Polyunsaturated fatty acids (PUFA), especially docosahexaenoic and arachidonic acids, as well as cholesterol are important for neural development and maintaining brain function. However, in contrast to cholesterol, the brain is unable to synthesize the required amounts of these PUFA de novo and requires a constant supply from plasma. Suggested pools of uptake include plasma unesterified PUFA or the uptake of PUFA-containing lipoproteins via lipoprotein receptors into endothelial cells of the blood brain barrier. Our study tested whether the very low density lipoprotein receptor (VLDLr) is necessary for maintaining brain PUFA and cholesterol concentrations. Moreover, since VLDLr knockout (VLDLr(-/-)) mice have been reported to have behavioural deficits, this study asked the question whether altered brain PUFA and cholesterol concentrations might be related to these deficits. VLDLr(-/-) and wild-type mice had ad libitum access to chow. At 7 weeks of age the mice were sacrificed, and the cortex, cerebellum, hippocampus, and the remainder of the brain were isolated for total fatty acid and cholesterol analyses. There were no differences in total lipid PUFA or cholesterol concentrations in any of the four brain regions between VLDLr(-/-) and wild-type mice. These findings demonstrate that the VLDLr is not necessary for maintaining brain PUFA concentrations and suggest that other mechanisms to transport PUFA into the brain must exist.
Tupur Rahman; Ameer Y Taha; Byung Jun Song; Sarah K Orr; Zhen Liu; Chuck T Chen; Richard P Bazinet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-27
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  82     ISSN:  1532-2823     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:    2010 Feb-Mar
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  141-5     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, FitzGerald Building, 150 College Street, Room 306, Toronto, ON, Canada.
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MeSH Terms
Arachidonic Acid / metabolism
Behavior, Animal
Body Weight / genetics,  physiology
Brain / metabolism*
Cholesterol / metabolism
Chromatography, Gas
Docosahexaenoic Acids / metabolism
Fatty Acids, Unsaturated / metabolism*
Gas Chromatography-Mass Spectrometry
Mice, Knockout
Receptors, LDL / genetics,  physiology*
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Receptors, LDL; 0/VLDL receptor; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid; 57-88-5/Cholesterol

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