Document Detail


The vertebrate cell kinetochore and its roles during mitosis.
MedLine Citation:
PMID:  9704407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A replicated chromosome possesses two discrete, complex, dynamic, macromolecular assemblies, known as kinetochores, that are positioned on opposite sides of the primary constriction of the chromosome. Here, the authors review how kinetochores control chromosome segregation during mitosis in vertebrates. They attach the chromosome to the opposing spindle poles by trapping the dynamic plus-ends of microtubules growing from the poles. They then produce much of the force for chromosome poleward motion, regulate when this force is applied, and act as a site for microtubule assembly and disassembly. Finally, they control the metaphase-anaphase transition by inhibiting chromatid separation until the chromatids are properly attached.
Authors:
C L Rieder; E D Salmon
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Trends in cell biology     Volume:  8     ISSN:  0962-8924     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-11-09     Completed Date:  1998-11-09     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  310-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatids
Humans
Kinetochores / physiology*
Mitosis / physiology*
Signal Transduction
Spindle Apparatus
Vertebrates
Grant Support
ID/Acronym/Agency:
GMS 24364/GM/NIGMS NIH HHS; GMS 40198/GM/NIGMS NIH HHS; P41-01219//PHS HHS; R01 GM040198/GM/NIGMS NIH HHS; R01 GM040198-15/GM/NIGMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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