Document Detail


On-versus Off-Pump Coronary Artery Bypass Grafting: No Difference in Early Postoperative Kidney Function Based on TNF-α or C-Reactive Protein.
MedLine Citation:
PMID:  22969775     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND/AIMS: There are controversial data about renal function following off-pump coronary artery bypass grafting (CABG). The present study aimed to evaluate renal function changes 24 h after on- and off-pump CABG, as well as renal function correlated with high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α). METHODS: Ninety patients with coronary artery disease referred to our center for CABG from July 2006 to November 2007 were enrolled in the study. Patients were equally and randomly divided in two groups, on- and off-pump. Serum levels of creatinine (Cr), blood urea nitrogen, creatinine clearance (CrCl), hs-CRP, and TNF-α were determined immediately before and 24 h after surgery. RESULTS: Cr and CrCl changes after surgery were not significantly different between the two groups; however, blood urea nitrogen levels after surgery were significantly higher in the on-pump group (p = 0.035). No statistically significant difference was noted between the two groups in terms of changes in levels of hs-CRP and TNF-α (p = 0.350 and 0.805, respectively). The changes in CrCl levels had no significant correlation with hs-CRP and TNF-α. CONCLUSIONS: The early Cr and CrCl levels after surgery are not significantly different in on- and off-pump groups. The early renal function after on- or off-pump CABG is not correlated with the levels of inflammatory markers including hs-CRP and TNF-α.
Authors:
Nariman Nezami; Hassan Djavadzadegan; Haleh Tabatabaie-Adl; Amir Hamdi; Kazem Ghobadi; Sona Ghorashi; Babak Hajhosseini
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-27
Journal Detail:
Title:  Cardiorenal medicine     Volume:  2     ISSN:  1664-5502     ISO Abbreviation:  Cardiorenal Med     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101554863     Medline TA:  Cardiorenal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  190-199     Citation Subset:  -    
Affiliation:
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
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