Document Detail

A versatile building block: the structures and functions of negative-sense single-stranded RNA virus nucleocapsid proteins.
MedLine Citation:
PMID:  23136065     Owner:  NLM     Status:  MEDLINE    
Nucleocapsid protein (NPs) of negative-sense single-stranded RNA (-ssRNA) viruses function in different stages of viral replication, transcription, and maturation. Structural investigations show that -ssRNA viruses that encode NPs preliminarily serve as structural building blocks that encapsidate and protect the viral genomic RNA and mediate the interaction between genomic RNA and RNA-dependent RNA polymerase. However, recent structural results have revealed other biological functions of -ssRNA viruses that extend our understanding of the versatile roles of virally encoded NPs.
Yuna Sun; Yu Guo; Zhiyong Lou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-11-08
Journal Detail:
Title:  Protein & cell     Volume:  3     ISSN:  1674-8018     ISO Abbreviation:  Protein Cell     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-09-30     Revised Date:  2014-03-13    
Medline Journal Info:
Nlm Unique ID:  101532368     Medline TA:  Protein Cell     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  893-902     Citation Subset:  IM    
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MeSH Terms
Capsid / metabolism
Lassa virus / chemistry,  physiology
Nucleocapsid Proteins / chemistry*,  metabolism*
Orthobunyavirus / chemistry,  physiology
RNA Viruses / chemistry*,  physiology
Reg. No./Substance:
0/Nucleocapsid Proteins

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