Document Detail


Is ventriculomegaly in idiopathic normal pressure hydrocephalus associated with a transmantle gradient in pulsatile intracranial pressure?
MedLine Citation:
PMID:  20130957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: In patients with idiopathic normal pressure hydrocephalus (iNPH) and ventriculomegaly, examine whether there is a gradient in pulsatile intracranial pressure (ICP) from within the cerebrospinal fluid (CSF) of cerebral ventricles (ICP(IV)) to the subdural (ICP(SD)) compartment. We hypothesized that pulsatile ICP is higher within the ventricular CSF. METHODS: The material includes 10 consecutive iNPH patients undergoing diagnostic ICP monitoring as part of pre-operative work-up. Eight patients had simultaneous ICP(IV) and ICP(SD) signals, and two patients had simultaneous signals from the lateral ventricle (ICP(IV)) and the brain parenchyma (ICP(PAR)). Intracranial pulsatility was characterized by the wave amplitude, rise time, and rise time coefficient; static ICP was characterized by mean ICP. RESULTS: None of the patients demonstrated gradients in pulsatile ICP, that is, we found no evidence of higher pulsatile ICP within the CSF of the cerebral ventricles (ICP(IV)), as compared to either the subdural (ICP(SD)) compartment or within the brain parenchyma (ICP(PAR)). During ventricular infusion testing in one patient, the ventricular ICP (ICP(IV)) was artificially increased, but this increase in ICP(IV) produced no gradient in pulsatile ICP from the ventricular CSF (ICP(IV)) to the parenchyma (ICP(PAR)). CONCLUSIONS: In this cohort of iNPH patients, we found no evidence of transmantle gradient in pulsatile ICP. The data gave no support to the hypothesis that pulsatile ICP is higher within the CSF of the cerebral ventricles (ICP(IV)) than within the subdural (ICP(SD)) compartment or the brain parenchyma (ICP(PAR)) in iNPH patients.
Authors:
Per Kristian Eide; Terje Saehle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-04
Journal Detail:
Title:  Acta neurochirurgica     Volume:  152     ISSN:  0942-0940     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  989-95     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Division of Clinical Neuroscience, Oslo University Hospital, Rikshospitalet HF, 0027 Oslo, Norway. per.kristian.eide@rikshospitalet.no
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Cerebral Ventricles / pathology*,  physiopathology*
Cerebrospinal Fluid Pressure / physiology*
Cohort Studies
Female
Humans
Hydrocephalus, Normal Pressure / physiopathology*,  surgery
Intracranial Pressure / physiology*
Magnetic Resonance Imaging
Male
Middle Aged
Prognosis
Pulsatile Flow / physiology*
Tomography, X-Ray Computed

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