Document Detail

The ventilatory response to hypoxia below the carbon dioxide threshold.
MedLine Citation:
PMID:  9018405     Owner:  NLM     Status:  MEDLINE    
The ventilatory response to acute progressive hypoxia below the carbon dioxide threshold using rebreathing was investigated. Nine subjects rebreathed after 5 min of hyperventilation to lower carbon dioxide stores. The rebreathing bag initially contained enough carbon dioxide to equilibrate alveolar and arterial partial pressures of carbon dioxide to the lowered mixed venous partial pressure (approximately equal to 30 mmHg), and enough oxygen to establish a chosen end-tidal partial pressure (50-70 mmHg), within one circulation time. During rebreathing, end-tidal partial pressure of carbon dioxide increased while end-tidal partial pressure of oxygen fell. Ventilation increased linearly with end-tidal carbon dioxide above a mean end-tidal partial pressure threshold of 39 +/- 2.7 mmHg. Below this peripheral-chemoreflex threshold, ventilation did not increase, despite a progressive fall in end-tidal oxygen partial pressure to a mean of 37 +/- 4.1 mmHg. In conclusion, hypoxia does not stimulate ventilation when carbon dioxide is below its peripheral-chemoreflex threshold.
T Rapanos; J Duffin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of applied physiology = Revue canadienne de physiologie appliquée     Volume:  22     ISSN:  1066-7814     ISO Abbreviation:  Can J Appl Physiol     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-04-15     Completed Date:  1997-04-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9306274     Medline TA:  Can J Appl Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  23-36     Citation Subset:  IM; S    
Department of Physiology, University of Toronto, ON.
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MeSH Terms
Acute Disease
Anoxia / metabolism,  physiopathology*
Carbon Dioxide / pharmacology*
Carotid Body / drug effects,  physiology
Chemoreceptor Cells / drug effects,  physiology
Maximum Allowable Concentration
Reference Values
Respiration / drug effects,  physiology
Ventilation-Perfusion Ratio / physiology*
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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