| The ventilatory response in severe metabolic acidosis. | |
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MedLine Citation:
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PMID: 6184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The ventilatory response to severe metabolic acidosis was studied by measuring arterial blood carbon dioxide tension and pH in sixty-seven patients with blood pH less than 7-10, none of whom had hypercapnia, pulmonary oedema, or chronic pulmonary insufficiency. The results were compared with those previously found in patients with uncomplicated diabetic ketoacidosis. 2. By that comparison, fifty-two of the sixty-seven patients with blood pH less than 7-10 were judged to have "appropriate hypocapnia", and fifteen had "submaximal hypocapnia". Thirteen of the latter fifteen had circulatory failture and/or acute hypoxia, and seven of nine in whom it was measured had plasma lactate greater than 9 mmol/1. 3. Hyperventilation was therefore usually well sustained in these patients with severe metabolic acidosis, except in most of those with acute tissue hypoxia. The latter may have had insufficient time to achieve maximum hyperventilation in response to their acidosis, or perhaps their submaximal hypercapnia presaged imminent failure of the hyperventilatory response. |
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Authors:
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M Fulop |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical science and molecular medicine Volume: 50 ISSN: 0301-0538 ISO Abbreviation: Clin Sci Mol Med Publication Date: 1976 May |
Date Detail:
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Created Date: 1976-08-23 Completed Date: 1976-08-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0367540 Medline TA: Clin Sci Mol Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 367-73 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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etiology,
physiopathology* Blood Blood Pressure Carbon Dioxide / blood Diabetes Complications Diabetes Mellitus / physiopathology Humans Hydrogen-Ion Concentration Lactates / blood Oxygen / blood Partial Pressure Respiration* |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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