| Is ventilatory efficiency (VE/VCO(2) slope) associated with right ventricular oxidative metabolism in patients with congestive heart failure? | |
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MedLine Citation:
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PMID: 18818123 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The relationship between minute ventilation and the rate of CO2 elimination (VE/VCO2 slope) is associated with mortality in patients with congestive heart failure (CHF). The VE/VCO2 slope > or =34 denotes a poor prognosis and has been proposed to reflect abnormalities in pulmonary perfusion. AIMS: To study whether increased VE/VCO2 slope is associated with elevated right ventricular (RV) oxidative metabolism relative to the left ventricle (LV). METHODS: 21 patients with stable NYHA II-III CHF underwent symptom limited cardiopulmonary exercise testing. Dynamic [(11)C]acetate positron emission tomography (PET) was used to measure oxidative metabolism (k(mono)) of the LV and RV. Corrected RV oxidative metabolism (RVOx) was calculated as RV/LV k(mono) ratio. RESULTS: Peak VO2 was 16.2+/-4.1 ml/min/kg and the VE/VCO2 slope was 33.4+/-6.1. LV and RV k(mono) were 0.046+/-0.009 and 0.037+/-0.007 min(-1), respectively, with a RVOx of 0.83+/-0.17. There was a good correlation between RVOx and the VE/VCO2 slope (r=0.61, p=0.0034). RVOx was 0.77+/-0.16 in patients with a VE/VCO2 slope <34 and 0.93+/-0.16 in patients with VE/VCO2 slope > or =34 (p=0.047). CONCLUSION: RVOx correlates with VE/VCO2 slope in CHF patients. This supports the hypothesis that pulmonary vascular resistance is a determinant of the VE/VCO2 slope. |
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Authors:
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Heikki Ukkonen; Ian G Burwash; William Dafoe; Robert A de Kemp; Haissam Haddad; Keiichiro Yoshinaga; Ross A Davies; Edward K Gannon; Jean N Dasilva; Rob S B Beanlands |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-09-24 |
Journal Detail:
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Title: European journal of heart failure Volume: 10 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-12-23 Completed Date: 2009-02-03 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1117-22 Citation Subset: IM |
Affiliation:
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Department of Medicine, Turku University Hospital, Turku, Finland. heikki.ukkonen@tyks.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Disease Progression Exercise Test Exercise Tolerance / physiology Female Heart Failure / metabolism*, physiopathology, radionuclide imaging Heart Ventricles / metabolism*, physiopathology, radionuclide imaging Humans Male Middle Aged Oxygen Consumption / physiology* Prognosis Pulmonary Gas Exchange Pulmonary Ventilation / physiology* Spirometry Tomography, Emission-Computed, Single-Photon Ventricular Function, Left / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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