| The ventilation distribution of helium-oxygen mixtures and the role of inertial losses in the presence of heterogeneous airway obstructions. | |
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MedLine Citation:
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PMID: 21316683 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The regional distribution of inhaled gas within the lung is affected in part by normal variations in airway geometry or by obstructions resulting from disease. In the present work, the effects of heterogeneous airway obstructions on the distribution of air and helium-oxygen were examined using an in vitro model, the two compartments of a dual adult test lung. Breathing helium-oxygen resulted in a consistently more uniform distribution, with the gas volume delivered to a severely obstructed compartment increased by almost 80%. An engineering approach to pipe flow was used to analyze the test lung and was extrapolated to a human lung model to show that the in vitro experimental parameters are relevant to the observed in vivo conditions. The engineering analysis also showed that helium-oxygen can decrease the relative weight of the flow resistance due to obstructions if they are inertial in nature (i.e., density dependent) due to either turbulence or laminar convective losses. |
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Authors:
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Ira M Katz; Andrew R Martin; Pierre-Antoine Muller; Karine Terzibachi; Chia-Hsiang Feng; Georges Caillibotte; Julien Sandeau; Joëlle Texereau |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-11 |
Journal Detail:
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Title: Journal of biomechanics Volume: - ISSN: 1873-2380 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0157375 Medline TA: J Biomech Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Medical Gases Group, Air Liquide Santé International, Centre de Recherche Claude Delorme, 1 Chemin de la Porte des Loges, B.P. 126, Les Loges-en-Josas 78354, France; Department of Mechanical Engineering, Lafayette College, Easton, PA 18042, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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