| A venlafaxine and mirtazapine-induced serotonin syndrome confirmed by de- and re-challenge. | |
| | |
MedLine Citation:
|
PMID: 22752315 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Case description A 85 year old woman with a history of severe depression treated with mirtazapine and venlafaxine was admitted to the hospital twice after progressive deterioration of her general condition evolving to unconsciousness. Clinicians diagnosed a metabolic encephalopathy caused by a urinary tract infection which was treated appropriately. Although mirtazapine was stopped during the first hospitalization, the patient's general practitioner restarted mirtazapine four days before readmission. During rehospitalization, she developed extreme restlessness, hyperreflexia and an increased tone in the lower limbs. She was hypertensive and tachycardic. Excessive sweating, elevated creatine kinase levels and bilateral mydriasis were noticed. Urinary analysis showed positive levels of mirtazapine and venlafaxine and both drugs were withdrawn. Symptoms resolved within 48 h after discontinuation of her antidepressants. Conclusion To our knowledge, this is the first case of the serotonin syndrome confirmed by a positive challenge, de-challenge and re-challenge. |
| | |
Authors:
|
Liesbeth Decoutere; Sabrina De Winter; Liesbeth Vander Weyden; Isabel Spriet; Maarten Schrooten; Jos Tournoy; Katleen Fagard |
Related Documents
:
|
18816255 - Cardiac sarcoidosis mimicking takotsubo syndrome. 21470865 - Correction of knee deformity in patients with ellis-van creveld syndrome: a case report... 21225435 - Sotos syndrome and scoliosis surgical treatment: a 10-year follow-up. 5571455 - Hydroxyapatite in the pathogenesis of cystic fibrosis. 7148385 - Balint's syndrome. report of four cases with watershed parieto-occipital lesions from v... 8059845 - Bilateral inferior petrosal sinus corticotropin sampling with corticotropin-releasing h... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-3 |
Journal Detail:
|
Title: International journal of clinical pharmacy Volume: - ISSN: 2210-7711 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-7-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101554912 Medline TA: Int J Clin Pharm Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Pharmacy Department, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium, liesbeth.decoutere@uzleuven.be. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The extent of cardiac myosin binding protein-C phosphorylation modulates actomyosin function in a gr...
Next Document: AHL signaling molecules with a large acyl chain enhance biofilm formation on sulfur and metal sulfid...