Document Detail


The velocity of cardiac sarcomere shortening: mechanisms and implications.
MedLine Citation:
PMID:  22752243     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A classical paper published by Michael Barany almost 50 years ago demonstrated a tight correlation between the mechanical parameter of maximal velocity of shortening and the biochemical parameter of myosin ATPase activity in a wide spectrum of species. Here, we review the determinants of muscle dynamics by mechanical load and the relation between sarcomere shortening velocity and cross-bridge dynamics in rat myocardium containing a range of fast and slow myosin. Observations from molecular level to mechanics of the intact human heart suggest that cardiac actin-myosin kinetic properties are matched so as to optimize myocardial strain rate and allow for the maximum rate of hydraulic energy output observed during ejection in the whole ventricle.
Authors:
Pieter P de Tombe; Henk E D J Ter Keurs
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-30
Journal Detail:
Title:  Journal of muscle research and cell motility     Volume:  -     ISSN:  1573-2657     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006298     Medline TA:  J Muscle Res Cell Motil     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cell and Molecular Physiology, Loyola University School of Medicine, 2160 South First Avenue, Maywood, IL, 60153, USA.
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