Document Detail

The velocity of cardiac sarcomere shortening: mechanisms and implications.
MedLine Citation:
PMID:  22752243     Owner:  NLM     Status:  Publisher    
A classical paper published by Michael Barany almost 50 years ago demonstrated a tight correlation between the mechanical parameter of maximal velocity of shortening and the biochemical parameter of myosin ATPase activity in a wide spectrum of species. Here, we review the determinants of muscle dynamics by mechanical load and the relation between sarcomere shortening velocity and cross-bridge dynamics in rat myocardium containing a range of fast and slow myosin. Observations from molecular level to mechanics of the intact human heart suggest that cardiac actin-myosin kinetic properties are matched so as to optimize myocardial strain rate and allow for the maximum rate of hydraulic energy output observed during ejection in the whole ventricle.
Pieter P de Tombe; Henk E D J Ter Keurs
Related Documents :
2230683 - Cardiac pathology in 470 consecutive forensic autopsies.
1182973 - Sudden death due to coronary artery disease. a clinical, hemodynamic, and angiographic ...
22868413 - Gated-spect myocardial perfusion imaging and coronary calcium score for evaluation of p...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-30
Journal Detail:
Title:  Journal of muscle research and cell motility     Volume:  -     ISSN:  1573-2657     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006298     Medline TA:  J Muscle Res Cell Motil     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Cell and Molecular Physiology, Loyola University School of Medicine, 2160 South First Avenue, Maywood, IL, 60153, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Influence of aeration intensity on mature aerobic granules in sequencing batch reactor.
Next Document:  Two-stage fermentation process for enhanced mannitol production using Candida magnoliae mutant R9.