| The vasodilator effect of coronary vascular endothelium in situ: its inactivation by hydroquinone. | |
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MedLine Citation:
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PMID: 3497279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies were carried out to demonstrate the presence of the endothelium derived relaxing factor (EDRF) in coronary arteries in situ and the effect of hydroquinone on this factor. The studies revealed the presence of EDRF in coronary arteries of rabbit hearts remaining in situ. EDRF was inactivated by left atrial injection of hydroquinone. In situ constriction of coronary arteries by vasopressin was markedly increased following exposure to hydroquinone, and the dilatory response to acetylcholine was absent. The experiments confirm the presence of the endothelium derived relaxing factor in coronary arteries in situ and its inactivation by hydroquinone. |
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Authors:
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R J Bing; M Saeed; A Hartmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of molecular and cellular cardiology Volume: 19 ISSN: 0022-2828 ISO Abbreviation: J. Mol. Cell. Cardiol. Publication Date: 1987 Apr |
Date Detail:
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Created Date: 1987-09-03 Completed Date: 1987-09-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0262322 Medline TA: J Mol Cell Cardiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 343-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / cytology, metabolism Coronary Vasospasm Coronary Vessels / anatomy & histology, drug effects* Dose-Response Relationship, Drug Endothelium / drug effects, physiology*, ultrastructure Hydroquinones / pharmacology* Image Processing, Computer-Assisted Microscopy, Electron, Scanning Nitric Oxide Rabbits Vasodilation / drug effects* Vasodilator Agents / antagonists & inhibitors* Vasopressins / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Hydroquinones; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 11000-17-2/Vasopressins; 123-31-9/hydroquinone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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