Document Detail


The vasodepressor action of prostacyclin (PGI2) and its effect on plasma angiotensin II and vasopressin in unanaesthetized normotensive and hypertensive rats.
MedLine Citation:
PMID:  391517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The action of prostacyclin (PGI2) on arterial pressure, heart rate, plasma concentration of angiotensin II and vasopressin was studied in groups of normal, renal hypertensive and DOC hypertensive rats. PGI2 was given by continuous iv. infusion at successive doses of 0.25, 0.5 and 1.0 microgram/kg x min, each rate for one hour. Arterial pressure was reduced to normal or below normal in the hypertensive rats, though the fall of blood pressure was greatest in the DOC hypertensive animals. Mean arterial pressure at the end of infusion was 89 mm Hg for normal rats, 87 mm Hg for renal hypertensive rats and 69 mm Hg for DOC hypertensive rats. Diastolic pressure fell more than systolic pressure suggesting a vasodilator mechanism. Heart rate was reduced significantly at the end of the infusion in the three groups of rats. Prostacyclin was also infused for 3 hours at a constant rate of 0.5 microgram/kg x min. The arterial pressure lowering effect was maintained throughout the infusion period.
Authors:
J Casals-Stenzel; J J Morton
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension     Volume:  1     ISSN:  0148-3927     ISO Abbreviation:  Clin Exp Hypertens     Publication Date:  1979  
Date Detail:
Created Date:  1980-03-27     Completed Date:  1980-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803060     Medline TA:  Clin Exp Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  577-96     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / blood*
Animals
Blood Pressure / drug effects*
Dose-Response Relationship, Drug
Epoprostenol / metabolism,  pharmacology*
Half-Life
Heart Rate / drug effects
Hypertension / drug therapy,  physiopathology
Male
Prostaglandins / pharmacology*
Rats
Vasopressins / blood*
Chemical
Reg. No./Substance:
0/Prostaglandins; 11000-17-2/Vasopressins; 11128-99-7/Angiotensin II; 35121-78-9/Epoprostenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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