Document Detail


The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation.
MedLine Citation:
PMID:  19076374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pulmonary vascular remodeling and inflammation often coexist in clinical and experimentally induced pulmonary arterial hypertension (PAH). In some instances, the pulmonary hypertension may be the primary, or at least the initial, problem, while inflammatory or autoimmune responses appear to initiate or dominate the picture in other cases. Based on studies in a model of PAH resulting from targeted deletion of the neuropeptide vasoactive intestinal peptide (VIP) gene, we propose that, at least in this experimental model, but possibly also in other situations, both vascular remodeling and inflammation may be mediated by one and the same mechanism: uncontrolled activation of calcineurin-NFAT (nuclear factor of activated T cells) signaling. If this hypothesis is validated, VIP would emerge as an endogenous modulator of pulmonary vascular remodeling and inflammation, through its suppression of NFAT activation.
Authors:
Sami I Said
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1144     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  148-53     Citation Subset:  IM    
Affiliation:
Pulmonary and Critical Care Medicine, SUNY Health Sciences Center, Stony Brook, NY 11794-8172, USA. sami.i.said@stonybrook.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Hypertension, Pulmonary / immunology*,  metabolism,  pathology
Lung / blood supply*,  metabolism*
Mice
Models, Animal
Models, Biological
NFATC Transcription Factors / metabolism
Pneumonia / metabolism*
Pulmonary Artery / metabolism,  pathology
Rats
Vasoactive Intestinal Peptide / genetics,  physiology*
Chemical
Reg. No./Substance:
0/NFATC Transcription Factors; 37221-79-7/Vasoactive Intestinal Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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